Antibody responses in vivo in chromosome instability syndromes with immunodeficiency

The primary IgG, IgM and IgA antibody responses to Helix pommatia haemocyanin (HPH) were defective in patients with ataxia telangiectasia (AT) and Nijmegen breakage syndrome (NBS). The results in patients with Bloom's syndrome (BS) were heterogeneous, but all showed abnormal kinetics of the IgG...

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Veröffentlicht in:	Clinical and experimental immunology 1984-09, Vol.57 (3), p.529-534
Hauptverfasser:	WEEMAES, C. M. R, THE, T. H, VAN MUNSTER, P. J. J, BAKKEREN, J. A. J. M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Ataxia Telangiectasia - immunology Biological and medical sciences Bloom Syndrome - immunology Child Child, Preschool Chromosome Aberrations - immunology Chromosome Disorders Chromosome fragility (bloom syndrome, ataxia telangiectasia, fanconi anemia, x-linked mental retardation...) Diphtheria Toxoid - immunology Female Hemocyanins - pharmacology Humans Immunoglobulin A - biosynthesis Immunoglobulin G - biosynthesis Immunoglobulin M - biosynthesis Immunologic Memory Male Medical genetics Medical sciences Poliovirus Vaccine, Inactivated - immunology Tetanus Toxoid - immunology
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Zusammenfassung:	The primary IgG, IgM and IgA antibody responses to Helix pommatia haemocyanin (HPH) were defective in patients with ataxia telangiectasia (AT) and Nijmegen breakage syndrome (NBS). The results in patients with Bloom's syndrome (BS) were heterogeneous, but all showed abnormal kinetics of the IgG response. The secondary response to diphtheria, tetanus and polio vaccine was normal in patients with AT and BS, but disturbed in the patients with NBS. The abnormalities of antibody response of AT and NBS are similar, although more profound in NBS; BS is different.
ISSN:	0009-9104 1365-2249