Imbalance of CD4 + CD45R+ and CD4+ CD29+ T helper cell subsets in patients with atopic diseases
SUMMARY To evaluate the proportion of helper cell subsets we studied 18 children with atopic dermatitis, 30 patients with asthma. 27 healthy age‐matched controls aged 1 to 17 years and 11 atopic controls without symptoms related to atopy, aged 9–22 years. Lymphocytes were isolated from heparinized p...
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| Veröffentlicht in: | Clinical and experimental immunology 1991-01, Vol.83 (1), p.25-29 |
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| creator | SCHAUER, U. JUNG, T. HEYMANNS, J. RIEGER, C. H. L |
| description | SUMMARY
To evaluate the proportion of helper cell subsets we studied 18 children with atopic dermatitis, 30 patients with asthma. 27 healthy age‐matched controls aged 1 to 17 years and 11 atopic controls without symptoms related to atopy, aged 9–22 years. Lymphocytes were isolated from heparinized peripheral blood and the proportion of CD4+CD29+ and CD4+CD45R+ cells was determined by double‐labelling immunofluorescence. Children with atopic dermatitis yielded a significantly (P |
| doi_str_mv | 10.1111/j.1365-2249.1991.tb05582.x |
| format | Article |
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To evaluate the proportion of helper cell subsets we studied 18 children with atopic dermatitis, 30 patients with asthma. 27 healthy age‐matched controls aged 1 to 17 years and 11 atopic controls without symptoms related to atopy, aged 9–22 years. Lymphocytes were isolated from heparinized peripheral blood and the proportion of CD4+CD29+ and CD4+CD45R+ cells was determined by double‐labelling immunofluorescence. Children with atopic dermatitis yielded a significantly (P<0.0l) higher proportion of CD4+CD45R+ (median 75%) cells compared with normal controls (median 66.6%). whereas the proportion of CD4+CD29+ cells was significantly (P<0.0l) lower in patients with atopic dermatitis (median 204 versus 29.6%). Interestingly, the percentage of CD4+CD45R+ cells shows an age‐dependent decline (r= ‐0.67, P<0.0l) in the control group, which is not found in the patient group.</description><identifier>ISSN: 0009-9104</identifier><identifier>EISSN: 1365-2249</identifier><identifier>DOI: 10.1111/j.1365-2249.1991.tb05582.x</identifier><identifier>PMID: 1703056</identifier><identifier>CODEN: CEXIAL</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Aging - immunology ; Allergic diseases ; allergy ; Antigens, CD - immunology ; Antigens, Differentiation - immunology ; asthma ; Asthma - immunology ; atopic dermatitis ; Biological and medical sciences ; CD4 Antigens - immunology ; Child ; Child, Preschool ; Dermatitis, Atopic - immunology ; Flow Cytometry ; General aspects ; Histocompatibility Antigens - immunology ; Humans ; Immunoglobulin E - analysis ; Immunopathology ; Infant ; Integrin beta1 ; Leukocyte Common Antigens ; Leukocyte Count ; lymphocyte subsets ; Medical sciences ; T-Lymphocyte Subsets - immunology ; T-Lymphocytes, Helper-Inducer - immunology</subject><ispartof>Clinical and experimental immunology, 1991-01, Vol.83 (1), p.25-29</ispartof><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5055-c21648bcd9d23ca7566f683393e304bc853c871676112911fc1d94997c671bac3</citedby><cites>FETCH-LOGICAL-c5055-c21648bcd9d23ca7566f683393e304bc853c871676112911fc1d94997c671bac3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1535447/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1535447/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,725,778,782,883,27911,27912,53778,53780</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19642901$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1703056$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SCHAUER, U.</creatorcontrib><creatorcontrib>JUNG, T.</creatorcontrib><creatorcontrib>HEYMANNS, J.</creatorcontrib><creatorcontrib>RIEGER, C. H. L</creatorcontrib><title>Imbalance of CD4 + CD45R+ and CD4+ CD29+ T helper cell subsets in patients with atopic diseases</title><title>Clinical and experimental immunology</title><addtitle>Clin Exp Immunol</addtitle><description>SUMMARY
To evaluate the proportion of helper cell subsets we studied 18 children with atopic dermatitis, 30 patients with asthma. 27 healthy age‐matched controls aged 1 to 17 years and 11 atopic controls without symptoms related to atopy, aged 9–22 years. Lymphocytes were isolated from heparinized peripheral blood and the proportion of CD4+CD29+ and CD4+CD45R+ cells was determined by double‐labelling immunofluorescence. Children with atopic dermatitis yielded a significantly (P<0.0l) higher proportion of CD4+CD45R+ (median 75%) cells compared with normal controls (median 66.6%). whereas the proportion of CD4+CD29+ cells was significantly (P<0.0l) lower in patients with atopic dermatitis (median 204 versus 29.6%). Interestingly, the percentage of CD4+CD45R+ cells shows an age‐dependent decline (r= ‐0.67, P<0.0l) in the control group, which is not found in the patient group.</description><subject>Adolescent</subject><subject>Aging - immunology</subject><subject>Allergic diseases</subject><subject>allergy</subject><subject>Antigens, CD - immunology</subject><subject>Antigens, Differentiation - immunology</subject><subject>asthma</subject><subject>Asthma - immunology</subject><subject>atopic dermatitis</subject><subject>Biological and medical sciences</subject><subject>CD4 Antigens - immunology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Dermatitis, Atopic - immunology</subject><subject>Flow Cytometry</subject><subject>General aspects</subject><subject>Histocompatibility Antigens - immunology</subject><subject>Humans</subject><subject>Immunoglobulin E - analysis</subject><subject>Immunopathology</subject><subject>Infant</subject><subject>Integrin beta1</subject><subject>Leukocyte Common Antigens</subject><subject>Leukocyte Count</subject><subject>lymphocyte subsets</subject><subject>Medical sciences</subject><subject>T-Lymphocyte Subsets - immunology</subject><subject>T-Lymphocytes, Helper-Inducer - immunology</subject><issn>0009-9104</issn><issn>1365-2249</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkdtL5DAUxoOs6Hj5E4QgrC9Da05ubRZ2QcbbgCCIPoc0TZ0MnbbbdLz896bMoO7j5iE54fvOyRd-CJ0CSSGu82UKTIqEUq5SUArSoSBC5DR920GTT-kHmhBCVKKA8H10EMIyXqWUdA_tQUYYEXKC9HxVmNo01uG2wrNLjqfjLh6m2DTlWI53qqb4ES9c3bkeW1fXOKyL4IaAfYM7M3jXxPrVDwtshrbzFpc-OBNcOEK7lamDO96eh-jp-upxdpvc3d_MZxd3iRUxemIpSJ4XtlQlZdZkQspK5owp5hjhhc0Fs3kGMpMAVAFUFkrFlcqszKAwlh2iP5u53bpYudLGQL2pddf7lenfdWu8_ldp_EI_ty8aBBOcZ3HA2XZA3_5duzDolQ_jV03j2nXQOeGUcEmi8dfGaPs2hN5Vn48A0SMevdQjAz0y0CMevcWj32LzyfeYX60bHlH_udVNsKau-kjGhy-bkpwqAtH3e-N79bV7_48EenY1p4J9APtsqUQ</recordid><startdate>199101</startdate><enddate>199101</enddate><creator>SCHAUER, U.</creator><creator>JUNG, T.</creator><creator>HEYMANNS, J.</creator><creator>RIEGER, C. H. L</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>199101</creationdate><title>Imbalance of CD4 + CD45R+ and CD4+ CD29+ T helper cell subsets in patients with atopic diseases</title><author>SCHAUER, U. ; JUNG, T. ; HEYMANNS, J. ; RIEGER, C. H. L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5055-c21648bcd9d23ca7566f683393e304bc853c871676112911fc1d94997c671bac3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Adolescent</topic><topic>Aging - immunology</topic><topic>Allergic diseases</topic><topic>allergy</topic><topic>Antigens, CD - immunology</topic><topic>Antigens, Differentiation - immunology</topic><topic>asthma</topic><topic>Asthma - immunology</topic><topic>atopic dermatitis</topic><topic>Biological and medical sciences</topic><topic>CD4 Antigens - immunology</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Dermatitis, Atopic - immunology</topic><topic>Flow Cytometry</topic><topic>General aspects</topic><topic>Histocompatibility Antigens - immunology</topic><topic>Humans</topic><topic>Immunoglobulin E - analysis</topic><topic>Immunopathology</topic><topic>Infant</topic><topic>Integrin beta1</topic><topic>Leukocyte Common Antigens</topic><topic>Leukocyte Count</topic><topic>lymphocyte subsets</topic><topic>Medical sciences</topic><topic>T-Lymphocyte Subsets - immunology</topic><topic>T-Lymphocytes, Helper-Inducer - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SCHAUER, U.</creatorcontrib><creatorcontrib>JUNG, T.</creatorcontrib><creatorcontrib>HEYMANNS, J.</creatorcontrib><creatorcontrib>RIEGER, C. H. L</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Clinical and experimental immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SCHAUER, U.</au><au>JUNG, T.</au><au>HEYMANNS, J.</au><au>RIEGER, C. H. L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Imbalance of CD4 + CD45R+ and CD4+ CD29+ T helper cell subsets in patients with atopic diseases</atitle><jtitle>Clinical and experimental immunology</jtitle><addtitle>Clin Exp Immunol</addtitle><date>1991-01</date><risdate>1991</risdate><volume>83</volume><issue>1</issue><spage>25</spage><epage>29</epage><pages>25-29</pages><issn>0009-9104</issn><eissn>1365-2249</eissn><coden>CEXIAL</coden><abstract>SUMMARY
To evaluate the proportion of helper cell subsets we studied 18 children with atopic dermatitis, 30 patients with asthma. 27 healthy age‐matched controls aged 1 to 17 years and 11 atopic controls without symptoms related to atopy, aged 9–22 years. Lymphocytes were isolated from heparinized peripheral blood and the proportion of CD4+CD29+ and CD4+CD45R+ cells was determined by double‐labelling immunofluorescence. Children with atopic dermatitis yielded a significantly (P<0.0l) higher proportion of CD4+CD45R+ (median 75%) cells compared with normal controls (median 66.6%). whereas the proportion of CD4+CD29+ cells was significantly (P<0.0l) lower in patients with atopic dermatitis (median 204 versus 29.6%). Interestingly, the percentage of CD4+CD45R+ cells shows an age‐dependent decline (r= ‐0.67, P<0.0l) in the control group, which is not found in the patient group.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>1703056</pmid><doi>10.1111/j.1365-2249.1991.tb05582.x</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Aging - immunology Allergic diseases allergy Antigens, CD - immunology Antigens, Differentiation - immunology asthma Asthma - immunology atopic dermatitis Biological and medical sciences CD4 Antigens - immunology Child Child, Preschool Dermatitis, Atopic - immunology Flow Cytometry General aspects Histocompatibility Antigens - immunology Humans Immunoglobulin E - analysis Immunopathology Infant Integrin beta1 Leukocyte Common Antigens Leukocyte Count lymphocyte subsets Medical sciences T-Lymphocyte Subsets - immunology T-Lymphocytes, Helper-Inducer - immunology |
| title | Imbalance of CD4 + CD45R+ and CD4+ CD29+ T helper cell subsets in patients with atopic diseases |
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