Imbalance of CD4 + CD45R+ and CD4+ CD29+ T helper cell subsets in patients with atopic diseases

SUMMARY To evaluate the proportion of helper cell subsets we studied 18 children with atopic dermatitis, 30 patients with asthma. 27 healthy age‐matched controls aged 1 to 17 years and 11 atopic controls without symptoms related to atopy, aged 9–22 years. Lymphocytes were isolated from heparinized p...

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Veröffentlicht in:	Clinical and experimental immunology 1991-01, Vol.83 (1), p.25-29
Hauptverfasser:	SCHAUER, U., JUNG, T., HEYMANNS, J., RIEGER, C. H. L
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Aging - immunology Allergic diseases allergy Antigens, CD - immunology Antigens, Differentiation - immunology asthma Asthma - immunology atopic dermatitis Biological and medical sciences CD4 Antigens - immunology Child Child, Preschool Dermatitis, Atopic - immunology Flow Cytometry General aspects Histocompatibility Antigens - immunology Humans Immunoglobulin E - analysis Immunopathology Infant Integrin beta1 Leukocyte Common Antigens Leukocyte Count lymphocyte subsets Medical sciences T-Lymphocyte Subsets - immunology T-Lymphocytes, Helper-Inducer - immunology
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Zusammenfassung:	SUMMARY To evaluate the proportion of helper cell subsets we studied 18 children with atopic dermatitis, 30 patients with asthma. 27 healthy age‐matched controls aged 1 to 17 years and 11 atopic controls without symptoms related to atopy, aged 9–22 years. Lymphocytes were isolated from heparinized peripheral blood and the proportion of CD4+CD29+ and CD4+CD45R+ cells was determined by double‐labelling immunofluorescence. Children with atopic dermatitis yielded a significantly (P
ISSN:	0009-9104 1365-2249
DOI:	10.1111/j.1365-2249.1991.tb05582.x