Toxicity Tests in Animals: Extrapolating to Human Risks
The use of animal models in toxicity testing is debated. While alternatives are being developed, whole animal models remain the most widely used method for assessing toxicity risks to humans. Some difficulties with animal-to-human extrapolations are noted, particularly use of the Maximum Tolerated D...
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| Veröffentlicht in: | Environmental health perspectives 1993-10, Vol.101 (5), p.396-401 |
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| container_title | Environmental health perspectives |
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| creator | Maloney, Dennis |
| description | The use of animal models in toxicity testing is debated. While alternatives are being developed, whole animal models remain the most widely used method for assessing toxicity risks to humans. Some difficulties with animal-to-human extrapolations are noted, particularly use of the Maximum Tolerated Dose and methods used to estimate dose-response relationships. The potential of molecular toxicology for risk assessment is becoming more widely recognized. The risks of abandoning the animal model are discussed. The need to approach toxicity testing in an interdisciplinary fashion is stressed. |
| doi_str_mv | 10.1289/ehp.101-1519837 |
| format | Article |
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| ispartof | Environmental health perspectives, 1993-10, Vol.101 (5), p.396-401 |
| issn | 0091-6765 1552-9924 |
| language | eng |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; JSTOR Archive Collection A-Z Listing; PubMed Central |
| subjects | Animals Animals, Laboratory Carcinogens Chemical hazards Data Interpretation, Statistical Dosage Dose response relationship Dose-Response Relationship, Drug Environmental Pollutants - adverse effects Focus Humans Models, Biological Risk Risk analysis Toxicology Toxins Tumors |
| title | Toxicity Tests in Animals: Extrapolating to Human Risks |
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