Proinflammatory and anti-inflammatory cytokines in meningococcal disease

Interleukin-10 (IL-10), an anti-inflammatory cytokine, was measured in 131 children with meningococcal disease. IL-10 concentrations were significantly higher in children who died and correlated positively with proinflammatory cytokines. Children who die from meningococcal disease have high IL-10 co...

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Veröffentlicht in:	Archives of disease in childhood 1996-11, Vol.75 (5), p.453-454
Hauptverfasser:	Riordan, F A, Marzouk, O, Thomson, A P, Sills, J A, Hart, C A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Bacterial diseases Biological and medical sciences Biomarkers - blood Child Child, Preschool Human bacterial diseases Humans Infant Infectious diseases Interleukin-10 - blood Interleukin-6 - blood Medical sciences Meningococcal Infections - immunology Prospective Studies Shock, Septic - immunology Staphylococcal infections, streptococcal infections, pneumococcal infections Survival Rate Tumor Necrosis Factor-alpha - analysis
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Beschreibung
Zusammenfassung:	Interleukin-10 (IL-10), an anti-inflammatory cytokine, was measured in 131 children with meningococcal disease. IL-10 concentrations were significantly higher in children who died and correlated positively with proinflammatory cytokines. Children who die from meningococcal disease have high IL-10 concentrations, which do not suppress proinflammatory cytokines.
ISSN:	0003-9888 1468-2044
DOI:	10.1136/adc.75.5.453