The effect of caffeine on prostaglandin output from the guinea‐pig uterus
1 Caffeine increased the outputs of prostaglandin F2α (PGF2α), PGE2 and 6‐keto‐PGF1α from the guinea‐pig uterus on days 7 and 15 of the oestrous cycle. The effect on PGE2 output depended on the age of the animals and was absent in younger guinea‐pigs (
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| Veröffentlicht in: | British journal of pharmacology 1994-09, Vol.113 (1), p.103-110 |
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| creator | Naderali, E.K. Poyser, N.L. |
| description | 1
Caffeine increased the outputs of prostaglandin F2α (PGF2α), PGE2 and 6‐keto‐PGF1α from the guinea‐pig uterus on days 7 and 15 of the oestrous cycle. The effect on PGE2 output depended on the age of the animals and was absent in younger guinea‐pigs ( |
| doi_str_mv | 10.1111/j.1476-5381.1994.tb16180.x |
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| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1510057</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>76925731</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5380-5d1adae493a9c3e5559511f66b5f72623fa6f9a3c0d1b269efbd68557f3cc3d73</originalsourceid><addsrcrecordid>eNqVkcFu1DAQhi0EKkvhEZAshLgleOLYjjmgQgUUUQkO5Ww5jr31KpsE24H2xiPwjDwJDhut4ITwxSP934z-mR-hJ0BKyO_5roRa8ILRBkqQsi5TCxwaUt7cQZujdBdtCCGiAGia--hBjDtCsijYCToRrJJAxAZ9uLq22DpnTcKjw0bn0g8WjwOewhiT3vZ66PyAxzlNc8IujHuccs92zpj--f3H5Ld4TjbM8SG653Qf7aP1P0Wf3765Or8oLj--e3_-6rIw2RYpWAe607aWVEtDLWNMMgDHecucqHhFneZOampIB23FpXVtxxvGhKPG0E7QU_TyMHea273tjB1S0L2agt_rcKtG7dXfyuCv1Xb8qoABIWwZ8GwdEMYvs41J7X00ts-r2nGOSnBZZQz-CQLnTBKQGXxxAE0-WgzWHd0AUUtmaqeWYNQSjFoyU2tm6iY3P_5zn2PrGlLWn666jkb3LujB-HjE6oqTqq4ydnbAvvne3v6HAfX608Xvkv4CXQW2YA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>16659019</pqid></control><display><type>article</type><title>The effect of caffeine on prostaglandin output from the guinea‐pig uterus</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Naderali, E.K. ; Poyser, N.L.</creator><creatorcontrib>Naderali, E.K. ; Poyser, N.L.</creatorcontrib><description>1
Caffeine increased the outputs of prostaglandin F2α (PGF2α), PGE2 and 6‐keto‐PGF1α from the guinea‐pig uterus on days 7 and 15 of the oestrous cycle. The effect on PGE2 output depended on the age of the animals and was absent in younger guinea‐pigs (<4 months). Theophylline also stimulated the outputs of PGF2α and 6‐keto‐PGF1α, but not the output of PGE2, from the day 7guinea‐pig uterus.
2
The stimulatory effects of caffeine on the outputs of PGF2α, PGE2 and 6‐keto‐PGF1α from the guinea‐pig uterus were not prevented by lack of extracellular calcium, ryanodine or ruthenium red (both inhibitors of calcium release via the ryanodine receptor), although the increase in PGF2α output tended to be slower when extracellular calcium was absent. Also, ryanodine flattened and broadened the peak of increased PGF2α release.
3
The calmodulin antagonists, W‐7 and trifluoperazine, had no inhibitory effect on the caffeine‐stimulated increases in uterine prostaglandin output. In fact, W‐7 (but not trifluoperazine) greatly potentiated the action of caffeine on uterine PGF2α output, but had little or no potentiating effect on the action of caffeine on uterine PGE2 and 6‐keto‐PGF1α outputs.
4
TMB‐8, an intracellular calcium antagonist, inhibited the increase in PGF2α output produced by caffeine without preventing the increases in outputs of PGE2 and 6‐keto‐PGF1α.
5
These studies suggest that caffeine stimulates uterine PGF2α synthesis and release by a mechanism dependent upon intracellular calcium, but this mechanism is not mediated by activation of any of the three well‐characterized ryanodine receptors or by calmodulin. Furthermore, the increases in the synthesis and release of PGE2 and 6‐keto‐PGF1α in the guinea‐pig uterus induced by caffeine appear to involve mechanism(s) different from that which stimulates PGF2α production.</description><identifier>ISSN: 0007-1188</identifier><identifier>EISSN: 1476-5381</identifier><identifier>DOI: 10.1111/j.1476-5381.1994.tb16180.x</identifier><identifier>PMID: 7529107</identifier><identifier>CODEN: BJPCBM</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Animals ; Biological and medical sciences ; Caffeine ; Caffeine - antagonists & inhibitors ; Caffeine - pharmacology ; Calcium - metabolism ; Calcium Channel Blockers - pharmacology ; Calmodulin - antagonists & inhibitors ; Female ; Fundamental and applied biological sciences. Psychology ; Gallic Acid - analogs & derivatives ; Gallic Acid - pharmacology ; Guinea Pigs ; Hormone metabolism and regulation ; Mammalian female genital system ; prostaglandins ; Prostaglandins - metabolism ; ruthenium red ; Ruthenium Red - pharmacology ; ryanodine ; Ryanodine - pharmacology ; Stimulation, Chemical ; Sulfonamides - pharmacology ; theophylline ; Theophylline - pharmacology ; TMB‐8 ; Trifluoperazine - pharmacology ; trifluoperazine, W‐7 ; uterus ; Uterus - drug effects ; Uterus - metabolism ; Vasodilator Agents - pharmacology ; Vertebrates: reproduction</subject><ispartof>British journal of pharmacology, 1994-09, Vol.113 (1), p.103-110</ispartof><rights>1994 British Pharmacological Society</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5380-5d1adae493a9c3e5559511f66b5f72623fa6f9a3c0d1b269efbd68557f3cc3d73</citedby><cites>FETCH-LOGICAL-c5380-5d1adae493a9c3e5559511f66b5f72623fa6f9a3c0d1b269efbd68557f3cc3d73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1510057/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1510057/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4260242$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7529107$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Naderali, E.K.</creatorcontrib><creatorcontrib>Poyser, N.L.</creatorcontrib><title>The effect of caffeine on prostaglandin output from the guinea‐pig uterus</title><title>British journal of pharmacology</title><addtitle>Br J Pharmacol</addtitle><description>1
Caffeine increased the outputs of prostaglandin F2α (PGF2α), PGE2 and 6‐keto‐PGF1α from the guinea‐pig uterus on days 7 and 15 of the oestrous cycle. The effect on PGE2 output depended on the age of the animals and was absent in younger guinea‐pigs (<4 months). Theophylline also stimulated the outputs of PGF2α and 6‐keto‐PGF1α, but not the output of PGE2, from the day 7guinea‐pig uterus.
2
The stimulatory effects of caffeine on the outputs of PGF2α, PGE2 and 6‐keto‐PGF1α from the guinea‐pig uterus were not prevented by lack of extracellular calcium, ryanodine or ruthenium red (both inhibitors of calcium release via the ryanodine receptor), although the increase in PGF2α output tended to be slower when extracellular calcium was absent. Also, ryanodine flattened and broadened the peak of increased PGF2α release.
3
The calmodulin antagonists, W‐7 and trifluoperazine, had no inhibitory effect on the caffeine‐stimulated increases in uterine prostaglandin output. In fact, W‐7 (but not trifluoperazine) greatly potentiated the action of caffeine on uterine PGF2α output, but had little or no potentiating effect on the action of caffeine on uterine PGE2 and 6‐keto‐PGF1α outputs.
4
TMB‐8, an intracellular calcium antagonist, inhibited the increase in PGF2α output produced by caffeine without preventing the increases in outputs of PGE2 and 6‐keto‐PGF1α.
5
These studies suggest that caffeine stimulates uterine PGF2α synthesis and release by a mechanism dependent upon intracellular calcium, but this mechanism is not mediated by activation of any of the three well‐characterized ryanodine receptors or by calmodulin. Furthermore, the increases in the synthesis and release of PGE2 and 6‐keto‐PGF1α in the guinea‐pig uterus induced by caffeine appear to involve mechanism(s) different from that which stimulates PGF2α production.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Caffeine</subject><subject>Caffeine - antagonists & inhibitors</subject><subject>Caffeine - pharmacology</subject><subject>Calcium - metabolism</subject><subject>Calcium Channel Blockers - pharmacology</subject><subject>Calmodulin - antagonists & inhibitors</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gallic Acid - analogs & derivatives</subject><subject>Gallic Acid - pharmacology</subject><subject>Guinea Pigs</subject><subject>Hormone metabolism and regulation</subject><subject>Mammalian female genital system</subject><subject>prostaglandins</subject><subject>Prostaglandins - metabolism</subject><subject>ruthenium red</subject><subject>Ruthenium Red - pharmacology</subject><subject>ryanodine</subject><subject>Ryanodine - pharmacology</subject><subject>Stimulation, Chemical</subject><subject>Sulfonamides - pharmacology</subject><subject>theophylline</subject><subject>Theophylline - pharmacology</subject><subject>TMB‐8</subject><subject>Trifluoperazine - pharmacology</subject><subject>trifluoperazine, W‐7</subject><subject>uterus</subject><subject>Uterus - drug effects</subject><subject>Uterus - metabolism</subject><subject>Vasodilator Agents - pharmacology</subject><subject>Vertebrates: reproduction</subject><issn>0007-1188</issn><issn>1476-5381</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkcFu1DAQhi0EKkvhEZAshLgleOLYjjmgQgUUUQkO5Ww5jr31KpsE24H2xiPwjDwJDhut4ITwxSP934z-mR-hJ0BKyO_5roRa8ILRBkqQsi5TCxwaUt7cQZujdBdtCCGiAGia--hBjDtCsijYCToRrJJAxAZ9uLq22DpnTcKjw0bn0g8WjwOewhiT3vZ66PyAxzlNc8IujHuccs92zpj--f3H5Ld4TjbM8SG653Qf7aP1P0Wf3765Or8oLj--e3_-6rIw2RYpWAe607aWVEtDLWNMMgDHecucqHhFneZOampIB23FpXVtxxvGhKPG0E7QU_TyMHea273tjB1S0L2agt_rcKtG7dXfyuCv1Xb8qoABIWwZ8GwdEMYvs41J7X00ts-r2nGOSnBZZQz-CQLnTBKQGXxxAE0-WgzWHd0AUUtmaqeWYNQSjFoyU2tm6iY3P_5zn2PrGlLWn666jkb3LujB-HjE6oqTqq4ydnbAvvne3v6HAfX608Xvkv4CXQW2YA</recordid><startdate>199409</startdate><enddate>199409</enddate><creator>Naderali, E.K.</creator><creator>Poyser, N.L.</creator><general>Blackwell Publishing Ltd</general><general>Nature Publishing</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>199409</creationdate><title>The effect of caffeine on prostaglandin output from the guinea‐pig uterus</title><author>Naderali, E.K. ; Poyser, N.L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5380-5d1adae493a9c3e5559511f66b5f72623fa6f9a3c0d1b269efbd68557f3cc3d73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Caffeine</topic><topic>Caffeine - antagonists & inhibitors</topic><topic>Caffeine - pharmacology</topic><topic>Calcium - metabolism</topic><topic>Calcium Channel Blockers - pharmacology</topic><topic>Calmodulin - antagonists & inhibitors</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gallic Acid - analogs & derivatives</topic><topic>Gallic Acid - pharmacology</topic><topic>Guinea Pigs</topic><topic>Hormone metabolism and regulation</topic><topic>Mammalian female genital system</topic><topic>prostaglandins</topic><topic>Prostaglandins - metabolism</topic><topic>ruthenium red</topic><topic>Ruthenium Red - pharmacology</topic><topic>ryanodine</topic><topic>Ryanodine - pharmacology</topic><topic>Stimulation, Chemical</topic><topic>Sulfonamides - pharmacology</topic><topic>theophylline</topic><topic>Theophylline - pharmacology</topic><topic>TMB‐8</topic><topic>Trifluoperazine - pharmacology</topic><topic>trifluoperazine, W‐7</topic><topic>uterus</topic><topic>Uterus - drug effects</topic><topic>Uterus - metabolism</topic><topic>Vasodilator Agents - pharmacology</topic><topic>Vertebrates: reproduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Naderali, E.K.</creatorcontrib><creatorcontrib>Poyser, N.L.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Naderali, E.K.</au><au>Poyser, N.L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of caffeine on prostaglandin output from the guinea‐pig uterus</atitle><jtitle>British journal of pharmacology</jtitle><addtitle>Br J Pharmacol</addtitle><date>1994-09</date><risdate>1994</risdate><volume>113</volume><issue>1</issue><spage>103</spage><epage>110</epage><pages>103-110</pages><issn>0007-1188</issn><eissn>1476-5381</eissn><coden>BJPCBM</coden><abstract>1
Caffeine increased the outputs of prostaglandin F2α (PGF2α), PGE2 and 6‐keto‐PGF1α from the guinea‐pig uterus on days 7 and 15 of the oestrous cycle. The effect on PGE2 output depended on the age of the animals and was absent in younger guinea‐pigs (<4 months). Theophylline also stimulated the outputs of PGF2α and 6‐keto‐PGF1α, but not the output of PGE2, from the day 7guinea‐pig uterus.
2
The stimulatory effects of caffeine on the outputs of PGF2α, PGE2 and 6‐keto‐PGF1α from the guinea‐pig uterus were not prevented by lack of extracellular calcium, ryanodine or ruthenium red (both inhibitors of calcium release via the ryanodine receptor), although the increase in PGF2α output tended to be slower when extracellular calcium was absent. Also, ryanodine flattened and broadened the peak of increased PGF2α release.
3
The calmodulin antagonists, W‐7 and trifluoperazine, had no inhibitory effect on the caffeine‐stimulated increases in uterine prostaglandin output. In fact, W‐7 (but not trifluoperazine) greatly potentiated the action of caffeine on uterine PGF2α output, but had little or no potentiating effect on the action of caffeine on uterine PGE2 and 6‐keto‐PGF1α outputs.
4
TMB‐8, an intracellular calcium antagonist, inhibited the increase in PGF2α output produced by caffeine without preventing the increases in outputs of PGE2 and 6‐keto‐PGF1α.
5
These studies suggest that caffeine stimulates uterine PGF2α synthesis and release by a mechanism dependent upon intracellular calcium, but this mechanism is not mediated by activation of any of the three well‐characterized ryanodine receptors or by calmodulin. Furthermore, the increases in the synthesis and release of PGE2 and 6‐keto‐PGF1α in the guinea‐pig uterus induced by caffeine appear to involve mechanism(s) different from that which stimulates PGF2α production.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>7529107</pmid><doi>10.1111/j.1476-5381.1994.tb16180.x</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Animals Biological and medical sciences Caffeine Caffeine - antagonists & inhibitors Caffeine - pharmacology Calcium - metabolism Calcium Channel Blockers - pharmacology Calmodulin - antagonists & inhibitors Female Fundamental and applied biological sciences. Psychology Gallic Acid - analogs & derivatives Gallic Acid - pharmacology Guinea Pigs Hormone metabolism and regulation Mammalian female genital system prostaglandins Prostaglandins - metabolism ruthenium red Ruthenium Red - pharmacology ryanodine Ryanodine - pharmacology Stimulation, Chemical Sulfonamides - pharmacology theophylline Theophylline - pharmacology TMB‐8 Trifluoperazine - pharmacology trifluoperazine, W‐7 uterus Uterus - drug effects Uterus - metabolism Vasodilator Agents - pharmacology Vertebrates: reproduction |
| title | The effect of caffeine on prostaglandin output from the guinea‐pig uterus |
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