The effect of caffeine on prostaglandin output from the guinea‐pig uterus

1 Caffeine increased the outputs of prostaglandin F2α (PGF2α), PGE2 and 6‐keto‐PGF1α from the guinea‐pig uterus on days 7 and 15 of the oestrous cycle. The effect on PGE2 output depended on the age of the animals and was absent in younger guinea‐pigs (

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Bibliographische Detailangaben
Veröffentlicht in:	British journal of pharmacology 1994-09, Vol.113 (1), p.103-110
Hauptverfasser:	Naderali, E.K., Poyser, N.L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Caffeine Caffeine - antagonists & inhibitors Caffeine - pharmacology Calcium - metabolism Calcium Channel Blockers - pharmacology Calmodulin - antagonists & inhibitors Female Fundamental and applied biological sciences. Psychology Gallic Acid - analogs & derivatives Gallic Acid - pharmacology Guinea Pigs Hormone metabolism and regulation Mammalian female genital system prostaglandins Prostaglandins - metabolism ruthenium red Ruthenium Red - pharmacology ryanodine Ryanodine - pharmacology Stimulation, Chemical Sulfonamides - pharmacology theophylline Theophylline - pharmacology TMB‐8 Trifluoperazine - pharmacology trifluoperazine, W‐7 uterus Uterus - drug effects Uterus - metabolism Vasodilator Agents - pharmacology Vertebrates: reproduction
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Beschreibung
Zusammenfassung:	1 Caffeine increased the outputs of prostaglandin F2α (PGF2α), PGE2 and 6‐keto‐PGF1α from the guinea‐pig uterus on days 7 and 15 of the oestrous cycle. The effect on PGE2 output depended on the age of the animals and was absent in younger guinea‐pigs (
ISSN:	0007-1188 1476-5381
DOI:	10.1111/j.1476-5381.1994.tb16180.x