Herd immunity from meningococcal serogroup C conjugate vaccination in England: database analysis

These data show that, in addition to direct protection, meningococcal conjugate vaccine contributes to the control of meningococcal infection by indirect protection, by reducing the attack rate in the unvaccinated population by 67%. These observations may be explained by a natural decline in the inc...

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Veröffentlicht in:	BMJ 2003-02, Vol.326 (7385), p.365-366
Hauptverfasser:	Ramsay, Mary E, Andrews, Nick J, Trotter, Caroline L, Kaczmarski, Edward B, Miller, Elizabeth
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adolescents Age groups Bacteria Bacterial diseases Bacterial diseases of the nervous system. Bacterial myositis Biological and medical sciences Child Child, Preschool Children Children & youth Cohort Studies Confidence Intervals Conjugate vaccines Depopulation England - epidemiology Herd immunity Human bacterial diseases Humans Immune system diseases Immunity, Herd - immunology Immunization Infant Infant, Newborn Infectious diseases Mass Vaccination - methods Medical sciences Meningococcal Infections - epidemiology Meningococcal Infections - immunology Meningococcal Infections - prevention & control Meningococcal Vaccines Neisseria meningitidis, Serogroup C Population estimates Public health Vaccination Vaccines, Conjugate
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Beschreibung
Zusammenfassung:	These data show that, in addition to direct protection, meningococcal conjugate vaccine contributes to the control of meningococcal infection by indirect protection, by reducing the attack rate in the unvaccinated population by 67%. These observations may be explained by a natural decline in the incidence of serogroup C disease, although this is unlikely.
ISSN:	0959-8138 0959-8146 1468-5833 1756-1833
DOI:	10.1136/bmj.326.7385.365