Activation of the Bcl-2 promoter by nerve growth factor is mediated by the p42/p44 MAPK cascade
The Bcl-2 protein has an anti-apoptotic effect in neuronal and other cell types. We show for the first time that the Bcl-2 promoter is activated by the neuronal survival factor nerve growth factor (NGF) and that this effect is dependent on a region of the promoter from −1472 to −1414. This activatio...
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| Veröffentlicht in: | Nucleic acids research 1999-05, Vol.27 (10), p.2086-2090 |
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| container_end_page | 2090 |
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| container_issue | 10 |
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| container_title | Nucleic acids research |
| container_volume | 27 |
| creator | Liu, Yu-Zhen Boxer, Linda M. Latchman, David S. |
| description | The Bcl-2 protein has an anti-apoptotic effect in neuronal and other cell types. We show for the first time that the Bcl-2 promoter is activated by the neuronal survival factor nerve growth factor (NGF) and that this effect is dependent on a region of the promoter from −1472 to −1414. This activation requires the Rap-1 G protein and the MEK-1 and p42/p44 MAPK enzymes but is independent of other NGF-activated signalling pathways involving protein kinase A or protein kinase C. |
| doi_str_mv | 10.1093/nar/27.10.2086 |
| format | Article |
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We show for the first time that the Bcl-2 promoter is activated by the neuronal survival factor nerve growth factor (NGF) and that this effect is dependent on a region of the promoter from −1472 to −1414. This activation requires the Rap-1 G protein and the MEK-1 and p42/p44 MAPK enzymes but is independent of other NGF-activated signalling pathways involving protein kinase A or protein kinase C.</description><identifier>ISSN: 0305-1048</identifier><identifier>EISSN: 1362-4962</identifier><identifier>DOI: 10.1093/nar/27.10.2086</identifier><identifier>PMID: 10219080</identifier><identifier>CODEN: NARHAD</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Animals ; Calcium-Calmodulin-Dependent Protein Kinases - metabolism ; Gene Expression Regulation - drug effects ; Genes, bcl-2 - drug effects ; GTP-Binding Proteins - metabolism ; MAP kinase ; MAP Kinase Kinase 1 ; MEK1 protein ; Mitogen-Activated Protein Kinase 1 - metabolism ; Mitogen-Activated Protein Kinase 3 ; Mitogen-Activated Protein Kinase Kinases ; Mitogen-Activated Protein Kinases ; Nerve Growth Factors - pharmacology ; p42 protein ; p44 protein ; PC12 Cells ; Promoter Regions, Genetic - drug effects ; protein kinase A ; Protein-Serine-Threonine Kinases - metabolism ; Protein-Tyrosine Kinases - metabolism ; rap GTP-Binding Proteins ; Rap-1 protein ; Rats ; Signal Transduction</subject><ispartof>Nucleic acids research, 1999-05, Vol.27 (10), p.2086-2090</ispartof><rights>Copyright Oxford University Press(England) May 15, 1999</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c547t-85a29f373e481f5c0e75fad66cad249ef3e3c4c825bd374a2d8877778654a4213</citedby><cites>FETCH-LOGICAL-c547t-85a29f373e481f5c0e75fad66cad249ef3e3c4c825bd374a2d8877778654a4213</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC148427/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC148427/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10219080$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Yu-Zhen</creatorcontrib><creatorcontrib>Boxer, Linda M.</creatorcontrib><creatorcontrib>Latchman, David S.</creatorcontrib><title>Activation of the Bcl-2 promoter by nerve growth factor is mediated by the p42/p44 MAPK cascade</title><title>Nucleic acids research</title><addtitle>Nucleic Acids Research</addtitle><description>The Bcl-2 protein has an anti-apoptotic effect in neuronal and other cell types. We show for the first time that the Bcl-2 promoter is activated by the neuronal survival factor nerve growth factor (NGF) and that this effect is dependent on a region of the promoter from −1472 to −1414. This activation requires the Rap-1 G protein and the MEK-1 and p42/p44 MAPK enzymes but is independent of other NGF-activated signalling pathways involving protein kinase A or protein kinase C.</description><subject>Animals</subject><subject>Calcium-Calmodulin-Dependent Protein Kinases - metabolism</subject><subject>Gene Expression Regulation - drug effects</subject><subject>Genes, bcl-2 - drug effects</subject><subject>GTP-Binding Proteins - metabolism</subject><subject>MAP kinase</subject><subject>MAP Kinase Kinase 1</subject><subject>MEK1 protein</subject><subject>Mitogen-Activated Protein Kinase 1 - metabolism</subject><subject>Mitogen-Activated Protein Kinase 3</subject><subject>Mitogen-Activated Protein Kinase Kinases</subject><subject>Mitogen-Activated Protein Kinases</subject><subject>Nerve Growth Factors - pharmacology</subject><subject>p42 protein</subject><subject>p44 protein</subject><subject>PC12 Cells</subject><subject>Promoter Regions, Genetic - drug effects</subject><subject>protein kinase A</subject><subject>Protein-Serine-Threonine Kinases - metabolism</subject><subject>Protein-Tyrosine Kinases - metabolism</subject><subject>rap GTP-Binding Proteins</subject><subject>Rap-1 protein</subject><subject>Rats</subject><subject>Signal Transduction</subject><issn>0305-1048</issn><issn>1362-4962</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtvEzEUhS0EoqGwZYksFuwm8fuxYJFGQFGLaCVeYmM5Hk_jMhkPthPov8ejVFVhgzf21f3O0b0-ADzHaI6RpovBpgWR9T0nSIkHYIapIA3TgjwEM0QRbzBi6gg8yfkaIcwwZ4_BEUYEa6TQDJilK2FvS4gDjB0sGw9PXN8QOKa4jcUnuL6Bg097D69S_FU2sLOuxARDhlvfBlt8OyGTcGRkMTIGPywvzqCz2dnWPwWPOttn_-z2Pgaf3775tDptzj--e79anjeOM1kaxS3RHZXUM4U77pCXvLOtENWDMO076qljThG-bqlklrRKyXqU4MwygukxeH3wHXfrOpfzQ0m2N2MKW5tuTLTB_N0ZwsZcxb3BTDEiq_7VrT7Fnzufi9mG7Hzf28HHXTZCSyKVFv8FsaR8Qiv48h_wOu7SUD_BEIQ411rpCs0PkEsx5-S7u4kxMlPApgZsiJzKKeAqeHF_z3v4IdEKNAcg5OJ_3_Vt-mGEpJKb02_fzerygp9dfvlqVvQPY2-veg</recordid><startdate>19990515</startdate><enddate>19990515</enddate><creator>Liu, Yu-Zhen</creator><creator>Boxer, Linda M.</creator><creator>Latchman, David S.</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>7QP</scope><scope>7QR</scope><scope>7SS</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19990515</creationdate><title>Activation of the Bcl-2 promoter by nerve growth factor is mediated by the p42/p44 MAPK cascade</title><author>Liu, Yu-Zhen ; Boxer, Linda M. ; Latchman, David S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c547t-85a29f373e481f5c0e75fad66cad249ef3e3c4c825bd374a2d8877778654a4213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Animals</topic><topic>Calcium-Calmodulin-Dependent Protein Kinases - metabolism</topic><topic>Gene Expression Regulation - drug effects</topic><topic>Genes, bcl-2 - drug effects</topic><topic>GTP-Binding Proteins - metabolism</topic><topic>MAP kinase</topic><topic>MAP Kinase Kinase 1</topic><topic>MEK1 protein</topic><topic>Mitogen-Activated Protein Kinase 1 - metabolism</topic><topic>Mitogen-Activated Protein Kinase 3</topic><topic>Mitogen-Activated Protein Kinase Kinases</topic><topic>Mitogen-Activated Protein Kinases</topic><topic>Nerve Growth Factors - pharmacology</topic><topic>p42 protein</topic><topic>p44 protein</topic><topic>PC12 Cells</topic><topic>Promoter Regions, Genetic - drug effects</topic><topic>protein kinase A</topic><topic>Protein-Serine-Threonine Kinases - metabolism</topic><topic>Protein-Tyrosine Kinases - metabolism</topic><topic>rap GTP-Binding Proteins</topic><topic>Rap-1 protein</topic><topic>Rats</topic><topic>Signal Transduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Yu-Zhen</creatorcontrib><creatorcontrib>Boxer, Linda M.</creatorcontrib><creatorcontrib>Latchman, David S.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nucleic acids research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Yu-Zhen</au><au>Boxer, Linda M.</au><au>Latchman, David S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Activation of the Bcl-2 promoter by nerve growth factor is mediated by the p42/p44 MAPK cascade</atitle><jtitle>Nucleic acids research</jtitle><addtitle>Nucleic Acids Research</addtitle><date>1999-05-15</date><risdate>1999</risdate><volume>27</volume><issue>10</issue><spage>2086</spage><epage>2090</epage><pages>2086-2090</pages><issn>0305-1048</issn><eissn>1362-4962</eissn><coden>NARHAD</coden><abstract>The Bcl-2 protein has an anti-apoptotic effect in neuronal and other cell types. We show for the first time that the Bcl-2 promoter is activated by the neuronal survival factor nerve growth factor (NGF) and that this effect is dependent on a region of the promoter from −1472 to −1414. This activation requires the Rap-1 G protein and the MEK-1 and p42/p44 MAPK enzymes but is independent of other NGF-activated signalling pathways involving protein kinase A or protein kinase C.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>10219080</pmid><doi>10.1093/nar/27.10.2086</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Nucleic acids research, 1999-05, Vol.27 (10), p.2086-2090 |
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| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_148427 |
| source | Oxford Journals Open Access Collection; MEDLINE; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Animals Calcium-Calmodulin-Dependent Protein Kinases - metabolism Gene Expression Regulation - drug effects Genes, bcl-2 - drug effects GTP-Binding Proteins - metabolism MAP kinase MAP Kinase Kinase 1 MEK1 protein Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 Mitogen-Activated Protein Kinase Kinases Mitogen-Activated Protein Kinases Nerve Growth Factors - pharmacology p42 protein p44 protein PC12 Cells Promoter Regions, Genetic - drug effects protein kinase A Protein-Serine-Threonine Kinases - metabolism Protein-Tyrosine Kinases - metabolism rap GTP-Binding Proteins Rap-1 protein Rats Signal Transduction |
| title | Activation of the Bcl-2 promoter by nerve growth factor is mediated by the p42/p44 MAPK cascade |
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