Activation of the Bcl-2 promoter by nerve growth factor is mediated by the p42/p44 MAPK cascade

The Bcl-2 protein has an anti-apoptotic effect in neuronal and other cell types. We show for the first time that the Bcl-2 promoter is activated by the neuronal survival factor nerve growth factor (NGF) and that this effect is dependent on a region of the promoter from −1472 to −1414. This activatio...

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Veröffentlicht in:	Nucleic acids research 1999-05, Vol.27 (10), p.2086-2090
Hauptverfasser:	Liu, Yu-Zhen, Boxer, Linda M., Latchman, David S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium-Calmodulin-Dependent Protein Kinases - metabolism Gene Expression Regulation - drug effects Genes, bcl-2 - drug effects GTP-Binding Proteins - metabolism MAP kinase MAP Kinase Kinase 1 MEK1 protein Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 Mitogen-Activated Protein Kinase Kinases Mitogen-Activated Protein Kinases Nerve Growth Factors - pharmacology p42 protein p44 protein PC12 Cells Promoter Regions, Genetic - drug effects protein kinase A Protein-Serine-Threonine Kinases - metabolism Protein-Tyrosine Kinases - metabolism rap GTP-Binding Proteins Rap-1 protein Rats Signal Transduction
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Zusammenfassung:	The Bcl-2 protein has an anti-apoptotic effect in neuronal and other cell types. We show for the first time that the Bcl-2 promoter is activated by the neuronal survival factor nerve growth factor (NGF) and that this effect is dependent on a region of the promoter from −1472 to −1414. This activation requires the Rap-1 G protein and the MEK-1 and p42/p44 MAPK enzymes but is independent of other NGF-activated signalling pathways involving protein kinase A or protein kinase C.
ISSN:	0305-1048 1362-4962
DOI:	10.1093/nar/27.10.2086