ON THE MECHANISM OF TACHYPHYLAXIS TO TYRAMINE IN THE ISOLATED RAT HEART

ON THE MECHANISM OF TACHYPHYLAXIS TO TYRAMINE IN THE ISOLATED RAT HEART

Tyramine was shown to release [3H]‐catecholamines from an isolated rat heart previously perfused with [3H]‐noradrenaline. With successive injections of tyramine the amount of [3H]‐catecholamine released fell progressively and there was a parallel decrease in the increment of amplitude and rate of co...

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Veröffentlicht in:British Journal of Pharmacology and Chemotherapy 1962-08, Vol.19 (1), p.56-63
Hauptverfasser: AXELROD, J., GORDON, EDNA, HERTTING, G., KOPIN, I. J., POTTER, L. T.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Catecholamines
Heart - pharmacology
Norepinephrine
Old Medline
Rats
Tachyphylaxis
Tyramine - pharmacology
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Zusammenfassung:Tyramine was shown to release [3H]‐catecholamines from an isolated rat heart previously perfused with [3H]‐noradrenaline. With successive injections of tyramine the amount of [3H]‐catecholamine released fell progressively and there was a parallel decrease in the increment of amplitude and rate of contraction of the heart. Reserpinized hearts were shown to take up less [3H]‐noradrenaline than normal hearts. Release of radioactivity and loss of responsiveness to tyramine occurred more rapidly in the reserpinized heart. In the same preparation the uptake of [14C]‐tyramine exceeded the quantity of the noradrenaline released.
ISSN:0366-0826
1476-5381
DOI:10.1111/j.1476-5381.1962.tb01426.x