Self-assembly of DNA—polymer complexes using template polymerization

The self-assembly of supramolecular complexes of nucleic acids and polymers is of relevance to several biological processes including viral and chromatin formation as well as gene therapy vector design. We now show that template polymerization facilitates condensation of DNA into particles that are

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Bibliographische Detailangaben
Veröffentlicht in:	Nucleic acids research 1998-09, Vol.26 (18), p.4178-4185
Hauptverfasser:	Trubetskoy, Vladimir S., Hanson, Lisa J., Slattum, Paul M., Hagstrom, James E., Budker, Vladimir G., Wolff, Jon A.
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Acrylates Animals Antigens, Polyomavirus Transforming - genetics Binding Sites Cross-Linking Reagents Dimerization DNA - chemistry DNA - genetics DNA - ultrastructure Genes, Reporter Luciferases - biosynthesis Luciferases - genetics Mice Microscopy, Electron Plasmids - chemistry Plasmids - genetics Plasmids - ultrastructure Polyethylene Glycols - chemistry Recombinant Proteins - biosynthesis Simian virus 40 - genetics Templates, Genetic Transfection
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Beschreibung
Zusammenfassung:	The self-assembly of supramolecular complexes of nucleic acids and polymers is of relevance to several biological processes including viral and chromatin formation as well as gene therapy vector design. We now show that template polymerization facilitates condensation of DNA into particles that are
ISSN:	0305-1048 1362-4962 1362-4962
DOI:	10.1093/nar/26.18.4178