No Evidence for Association with Parkinson Disease for 13 Single-Nucleotide Polymorphisms Identified by Whole-Genome Association Screening

Fewer than half of the SNPs (46%) showed allele frequency differences between cases and controls in the same direction as that reported by Maraganore et al.1 The combination of our data with those from the original report, with the use of the Mantel-Haenszel test statistic (Statsdirect) and correction for the 11 independent tests performed, revealed that only three markers (rs10200894, ss46548856, and rs7702187) retain any evidence of significance at the 5% level in the total data (table 1).