A Dichotomy in the Lipophilicity of Natural Estrogens, Xenoestrogens, and Phytoestrogens

Using two independent analyses, it is demonstrated that natural (e.g., estradiol) and some xenoestrogens (e.g., methoxychlor metabolite) are characterized by a lipophilic region that is absent in nonestrogens as well as in phytoestrogens. It is suggested that this lipophilic region affects binding t...

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Veröffentlicht in:	Environmental health perspectives 1997-04, Vol.105 (suppl 3), p.665-668
Hauptverfasser:	Cunningham, Albert R., Klopman, Gilles, Rosenkranz, Herbert S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Atoms Binding Sites Carcinogens - chemistry Carcinogens - metabolism Carcinogens - toxicity Environmental Health Establishing the Risks from Xenohormones Estrogen Antagonists - chemistry Estrogen Antagonists - metabolism Estrogen receptor modulators Estrogens Estrogens - chemistry Estrogens - metabolism Estrogens - toxicity Estrogens, Non-Steroidal - chemistry Estrogens, Non-Steroidal - metabolism Estrogens, Non-Steroidal - toxicity Female Functional groups Hydrogen In Vitro Techniques Isoflavones Lipid Metabolism Metabolites Models, Molecular Molecular Structure Molecules Phenols Phytoestrogens Plant Preparations Receptors, Estrogen - metabolism
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Beschreibung
Zusammenfassung:	Using two independent analyses, it is demonstrated that natural (e.g., estradiol) and some xenoestrogens (e.g., methoxychlor metabolite) are characterized by a lipophilic region that is absent in nonestrogens as well as in phytoestrogens. It is suggested that this lipophilic region affects binding to specific receptors and may, in fact, differentiate harmful from beneficial estrogens.
ISSN:	0091-6765 1552-9924
DOI:	10.1289/ehp.97105s3665