A murine monoclonal antibody against blood group H type-1 and -2 structures

A murine monoclonal antibody against blood group H type-1 and -2 structures

A murine anti-H monoclonal antibody was produced. This antibody, called sp115, is an IgM that does not agglutinate classical Bombay. Sp115 may differentiate the two categories of H-deficient phenotypes. It detects H substance in both plasma and fresh saliva. Tissue antigen is found when using this a...

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Veröffentlicht in:Immunology 1983-10, Vol.50 (2), p.215-221
Hauptverfasser: DOINEL, C, EDELMAN, L, ROUGER, P, LEBLANC, J, REVIRON, J, BACH, J. F, SALMON, C
Format: Artikel
Sprache:eng
Schlagworte:
ABO Blood-Group System - immunology
Animals
Antibodies, immunoglobulins
Antibodies, Monoclonal - immunology
Biological and medical sciences
Blood Group Antigens - immunology
Fluorescent Antibody Technique
Fucose - immunology
Fundamental and applied biological sciences. Psychology
Fundamental immunology
H-2 Antigens - immunology
Hemagglutination Inhibition Tests
Humans
Immunosorbent Techniques
Mice
Mice, Inbred C57BL
Molecular immunology
Oligosaccharides - immunology
Saliva - immunology
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Zusammenfassung:A murine anti-H monoclonal antibody was produced. This antibody, called sp115, is an IgM that does not agglutinate classical Bombay. Sp115 may differentiate the two categories of H-deficient phenotypes. It detects H substance in both plasma and fresh saliva. Tissue antigen is found when using this antibody. The specificity of sp115 antibody was determined by adsorption with, and elution from synthetic oligosaccharide immunoadsorbents. Sp115 does not distinguish H type-1 and H type 2-structures.
ISSN:0019-2805
1365-2567