Study of blood group B antigen with a specific monoclonal antibody (anti-B, b-183)

A murine anti-B monoclonal antibody was obtained by the hybridoma technique. This antibody called anti-B (b-183) is of IgM nature; it is capable of agglutinating normal B, B3, Bx, cis AB and some acquired B red cells. Its association constant is 1.1 X 10(8) l/mol, and appears high compared to those...

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Veröffentlicht in:	Immunology 1983-05, Vol.49 (1), p.77-82
Hauptverfasser:	Rouger, P, Edelman, L, Doinel, C, Reviron, J, Salmon, C, Bach, J F
Format:	Artikel
Sprache:	eng
Schlagworte:	ABO Blood-Group System - immunology Animals Antibodies, Monoclonal - immunology Antibody Specificity Erythrocytes - immunology Hemagglutination Humans Hybridomas - immunology Immunoglobulin M - immunology Isoantibodies - immunology Mice Mice, Inbred C57BL Thermodynamics
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Zusammenfassung:	A murine anti-B monoclonal antibody was obtained by the hybridoma technique. This antibody called anti-B (b-183) is of IgM nature; it is capable of agglutinating normal B, B3, Bx, cis AB and some acquired B red cells. Its association constant is 1.1 X 10(8) l/mol, and appears high compared to those of the monoclonal anti-A. This monoclonal anti-B was used to determine the number of B sites on B3 and Bx red cells.
ISSN:	0019-2805 1365-2567