Demonstration of pepsinogen C in human pancreatic islets

Pancreatic tissue from 16 post mortem kidney donors have been examined for the content of pepsinogens. A zymogen with electrophoretic mobility, isoelectric point and molecular weight equal to that of pepsinogen C of gastric origin was found in all specimens. A comparison between pepsinogen C extract...

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Veröffentlicht in:	Gut 1987-10, Vol.28 (10), p.1208-1214
Hauptverfasser:	Szecsi, P B, Halgreen, H, Poulsen, S S, Axelsson, C K, Damkjaer-Nielsen, M, Kjaer, T, Foltmann, B
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Electrophoresis, Agar Gel Electrophoresis, Polyacrylamide Gel Endocrine pancreas Fundamental and applied biological sciences. Psychology Gastric Mucosa - enzymology Humans Immunoenzyme Techniques Islets of Langerhans - analysis Islets of Langerhans - enzymology Isoelectric Focusing Morphology. Functional localizations Pepsinogens - analysis Pepsinogens - metabolism Vertebrates: endocrinology
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Zusammenfassung:	Pancreatic tissue from 16 post mortem kidney donors have been examined for the content of pepsinogens. A zymogen with electrophoretic mobility, isoelectric point and molecular weight equal to that of pepsinogen C of gastric origin was found in all specimens. A comparison between pepsinogen C extracted from pancreatic tissue and gastric mucosa demonstrated immunological identity. Quantitative measurements with a radioimmunoassay showed pepsinogen C concentrations in pancreatic tissue three to 80 times higher than those of blood serum. Immunohistochemical staining gave positive reaction for pepsinogen C only in the alpha cells of the pancreatic islets.
ISSN:	0017-5749 1468-3288 1458-3288
DOI:	10.1136/gut.28.10.1208