Review of clinical studies on clobazam

1 Clobazam was compared with placebo and diazepam in 45 double‐blind studies. 2 Clobazam dosage ranged from 5 mg daily (paediatric patients) to 120 mg daily (psychiatric in‐patients). Usual daily dosage in out‐ patient therapy ranged from 20‐30 mg clobazam. 3 Treatment duration varied from a few days up to 3.5 years. The usual duration of treatment was 2‐4 weeks. 4 Clobazam was shown to be an efficacious and well tolerated anxiolytic agent in various neurotic and psychosomatic disorders. 5 Dosages showing distinct anxiolytic effects in out‐patient therapy did not impair psychomotor performance.