Expression of interleukin-6 receptor on blood lymphocytes without in vitro activation
A monoclonal antibody against the interleukin-6 receptor (IL-6R) has been used in a high-sensitivity immunofluorescence technique to study receptor expression on unstimulated blood lymphocytes. Most CD4 cells express IL-6 receptor, whilst a small and variable proportion of CD8 and B cells are positi...
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| Veröffentlicht in: | Immunology 1992-06, Vol.76 (2), p.338-340 |
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| container_title | Immunology |
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| creator | ZOLA, H FLEGO, L |
| description | A monoclonal antibody against the interleukin-6 receptor (IL-6R) has been used in a high-sensitivity immunofluorescence technique to study receptor expression on unstimulated blood lymphocytes. Most CD4 cells express IL-6 receptor, whilst a small and variable proportion of CD8 and B cells are positive. CD4+ cells express higher levels of receptor than CD8+ T cells, and CD45RO+ cells express higher levels than CD45RA cells. |
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Psychology ; Fundamental immunology ; Humans ; Immunobiology ; Lymphocytes - immunology ; Lymphokines, interleukins ( function, expression) ; Receptors, Immunologic - analysis ; Receptors, Interleukin-6 ; Regulatory factors and their cellular receptors ; T-Lymphocytes - immunology</subject><ispartof>Immunology, 1992-06, Vol.76 (2), p.338-340</ispartof><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1421523/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1421523/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,725,778,782,883,53774,53776</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5442886$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1353064$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ZOLA, H</creatorcontrib><creatorcontrib>FLEGO, L</creatorcontrib><title>Expression of interleukin-6 receptor on blood lymphocytes without in vitro activation</title><title>Immunology</title><addtitle>Immunology</addtitle><description>A monoclonal antibody against the interleukin-6 receptor (IL-6R) has been used in a high-sensitivity immunofluorescence technique to study receptor expression on unstimulated blood lymphocytes. Most CD4 cells express IL-6 receptor, whilst a small and variable proportion of CD8 and B cells are positive. CD4+ cells express higher levels of receptor than CD8+ T cells, and CD45RO+ cells express higher levels than CD45RA cells.</description><subject>Analysis of the immune response. Humoral and cellular immunity</subject><subject>B-Lymphocytes - immunology</subject><subject>Biological and medical sciences</subject><subject>CD4-Positive T-Lymphocytes - immunology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Humans</subject><subject>Immunobiology</subject><subject>Lymphocytes - immunology</subject><subject>Lymphokines, interleukins ( function, expression)</subject><subject>Receptors, Immunologic - analysis</subject><subject>Receptors, Interleukin-6</subject><subject>Regulatory factors and their cellular receptors</subject><subject>T-Lymphocytes - immunology</subject><issn>0019-2805</issn><issn>1365-2567</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtKxDAUhoMo43h5BCELcVfIpUnbjSDDeIEBN866pOmJE-00NUlH5-0NWAZduTqE7893fs4RmlMuRcaELI7RnBBaZawk4hSdhfCWnpwIMUMzygUnMp-j9fJr8BCCdT12Bts-gu9gfLd9JrEHDUN0HifYdM61uNtvh43T-wgBf9q4cWNMf_DORu-w0tHuVEyqC3RiVBfgcprnaH2_fFk8Zqvnh6fF3SobGJcxa43hhWaccNZUAqiGsiVUVEwQQYoGKi0MA8MZpamuyUsiqwpKCawiRDaMn6PbH-8wNltoNfTRq64evN0qv6-dsvVf0ttN_ep2Nc0ZFYwnwc0k8O5jhBDrrQ0auk714MZQF5yUkovi3yCVjOaFoCl49bvSoct08cSvJ66CVp3xqtc2HGIiz1mZVn4DfHWLxw</recordid><startdate>19920601</startdate><enddate>19920601</enddate><creator>ZOLA, H</creator><creator>FLEGO, L</creator><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19920601</creationdate><title>Expression of interleukin-6 receptor on blood lymphocytes without in vitro activation</title><author>ZOLA, H ; FLEGO, L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p236t-dff37c23032b95e1ce8d0159250507be9c5f2ef3211530f480699e86e29006b23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Analysis of the immune response. Humoral and cellular immunity</topic><topic>B-Lymphocytes - immunology</topic><topic>Biological and medical sciences</topic><topic>CD4-Positive T-Lymphocytes - immunology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Humans</topic><topic>Immunobiology</topic><topic>Lymphocytes - immunology</topic><topic>Lymphokines, interleukins ( function, expression)</topic><topic>Receptors, Immunologic - analysis</topic><topic>Receptors, Interleukin-6</topic><topic>Regulatory factors and their cellular receptors</topic><topic>T-Lymphocytes - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ZOLA, H</creatorcontrib><creatorcontrib>FLEGO, L</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ZOLA, H</au><au>FLEGO, L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of interleukin-6 receptor on blood lymphocytes without in vitro activation</atitle><jtitle>Immunology</jtitle><addtitle>Immunology</addtitle><date>1992-06-01</date><risdate>1992</risdate><volume>76</volume><issue>2</issue><spage>338</spage><epage>340</epage><pages>338-340</pages><issn>0019-2805</issn><eissn>1365-2567</eissn><coden>IMMUAM</coden><abstract>A monoclonal antibody against the interleukin-6 receptor (IL-6R) has been used in a high-sensitivity immunofluorescence technique to study receptor expression on unstimulated blood lymphocytes. Most CD4 cells express IL-6 receptor, whilst a small and variable proportion of CD8 and B cells are positive. CD4+ cells express higher levels of receptor than CD8+ T cells, and CD45RO+ cells express higher levels than CD45RA cells.</abstract><cop>Oxford</cop><pub>Blackwell</pub><pmid>1353064</pmid><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Immunology, 1992-06, Vol.76 (2), p.338-340 |
| issn | 0019-2805 1365-2567 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1421523 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Analysis of the immune response. Humoral and cellular immunity B-Lymphocytes - immunology Biological and medical sciences CD4-Positive T-Lymphocytes - immunology Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Immunobiology Lymphocytes - immunology Lymphokines, interleukins ( function, expression) Receptors, Immunologic - analysis Receptors, Interleukin-6 Regulatory factors and their cellular receptors T-Lymphocytes - immunology |
| title | Expression of interleukin-6 receptor on blood lymphocytes without in vitro activation |
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