Expression of interleukin-6 receptor on blood lymphocytes without in vitro activation

A monoclonal antibody against the interleukin-6 receptor (IL-6R) has been used in a high-sensitivity immunofluorescence technique to study receptor expression on unstimulated blood lymphocytes. Most CD4 cells express IL-6 receptor, whilst a small and variable proportion of CD8 and B cells are positi...

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Veröffentlicht in:	Immunology 1992-06, Vol.76 (2), p.338-340
Hauptverfasser:	ZOLA, H, FLEGO, L
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of the immune response. Humoral and cellular immunity B-Lymphocytes - immunology Biological and medical sciences CD4-Positive T-Lymphocytes - immunology Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Immunobiology Lymphocytes - immunology Lymphokines, interleukins ( function, expression) Receptors, Immunologic - analysis Receptors, Interleukin-6 Regulatory factors and their cellular receptors T-Lymphocytes - immunology
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Beschreibung
Zusammenfassung:	A monoclonal antibody against the interleukin-6 receptor (IL-6R) has been used in a high-sensitivity immunofluorescence technique to study receptor expression on unstimulated blood lymphocytes. Most CD4 cells express IL-6 receptor, whilst a small and variable proportion of CD8 and B cells are positive. CD4+ cells express higher levels of receptor than CD8+ T cells, and CD45RO+ cells express higher levels than CD45RA cells.
ISSN:	0019-2805 1365-2567