Sialic acids of human large bowel mucosa: o-acylated variants in normal and malignant states

Five sialic acid variants have been demonstrated in normal, 'transitional', and tumour extracts of human large bowel mucosa by thin-layer chromatography. Two-dimensional thin-layer chromatography, with intermediate alkaline hydrolysis, confirmed that the variants were N-acetyl neuraminic a...

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Veröffentlicht in:	Gut 1978-07, Vol.19 (7), p.587-592
Hauptverfasser:	Rogers, C M, Cooke, K B, Filipe, M I
Format:	Artikel
Sprache:	eng
Schlagworte:	Acylation Animals Cattle Chromatography, Thin Layer Humans Intestinal Mucosa - metabolism Intestinal Neoplasms - metabolism Intestine, Large - metabolism Sialic Acids - metabolism
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Zusammenfassung:	Five sialic acid variants have been demonstrated in normal, 'transitional', and tumour extracts of human large bowel mucosa by thin-layer chromatography. Two-dimensional thin-layer chromatography, with intermediate alkaline hydrolysis, confirmed that the variants were N-acetyl neuraminic acids with additional O-acylation. Cases studied so far show changes in the proportions of these variants in malignancy.
ISSN:	0017-5749 1468-3288 1458-3288
DOI:	10.1136/gut.19.7.587