The effect of prolonged pancreatic secretion on blood acid-base balance in the conscious dog

Prolonged near maximal pancreatic secretion in conscious dogs has been found to result in a metabolic acidosis. This is mild and is accompanied by respiratory and other forms of compensation. Measurements of blood bicarbonate or base-excess changes cannot be used to estimate pancreatic bicarbonate o...

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Veröffentlicht in:	Gut 1971-11, Vol.12 (11), p.918-921
Hauptverfasser:	Fawcett, A. N., Newman, C. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid-Base Equilibrium Acidosis - etiology Animals Bicarbonates - analysis Bicarbonates - blood Bicarbonates - metabolism Blood Carbon Dioxide - blood Consciousness Dogs Hydrogen-Ion Concentration Pancreas - metabolism Pancreatic Juice - analysis Pancreatic Juice - metabolism Respiration Secretin Secretory Rate
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Beschreibung
Zusammenfassung:	Prolonged near maximal pancreatic secretion in conscious dogs has been found to result in a metabolic acidosis. This is mild and is accompanied by respiratory and other forms of compensation. Measurements of blood bicarbonate or base-excess changes cannot be used to estimate pancreatic bicarbonate output. The acidosis caused by pancreatic secretion cannot explain the changes in bicarbonate concentration seen in pancreatic juice during prolonged secretion.
ISSN:	0017-5749 1468-3288 1458-3288
DOI:	10.1136/gut.12.11.918