Inhibition by somatostatin (growth-hormone release-inhibiting hormone, GH-RIH) of gastric acid and pepsin and G-cell release of gastrin

Inhibition by somatostatin (growth-hormone release-inhibiting hormone, GH-RIH) of gastric acid and pepsin and G-cell release of gastrin

Somatostatin (cyclic growth-hormone release-inhibiting hormone--GH-RIH) was infused into dogs with gastric fistulae. Somatostatin inhibited gastric acid response to four gastric stimulants--insulin, food, histamine, and pentagastrin. Histamine- and pentagastrin-stimulated pepsins were inhibited simi...

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Veröffentlicht in:Gut 1978-04, Vol.19 (4), p.315-320
Hauptverfasser: Barros D'sa, A A, Bloom, S R, Baron, J H
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Dogs
Food
Gastric Juice - metabolism
Gastrins - metabolism
Histamine - pharmacology
Insulin - pharmacology
Pentagastrin - pharmacology
Pepsin A - metabolism
Secretory Rate - drug effects
Somatostatin - pharmacology
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Zusammenfassung:Somatostatin (cyclic growth-hormone release-inhibiting hormone--GH-RIH) was infused into dogs with gastric fistulae. Somatostatin inhibited gastric acid response to four gastric stimulants--insulin, food, histamine, and pentagastrin. Histamine- and pentagastrin-stimulated pepsins were inhibited similarly to inhibition of acid. Somatostatin inhibited the gastrin response to insulin and food.
ISSN:0017-5749
1468-3288
1458-3288
DOI:10.1136/gut.19.4.315