Jaundice due to iprindole
Twenty-one patients treated for depression with iprindole developed evidence of liver damage: 15 were jaundiced, five had bilirubinuria, and one had pruritus. These complications occurred between four and 21 days after initial exposure to the drug. All patients recovered. Light and electron microsco...
Gespeichert in:
| Veröffentlicht in: | Gut 1971-09, Vol.12 (9), p.705-708 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 708 |
|---|---|
| container_issue | 9 |
| container_start_page | 705 |
| container_title | Gut |
| container_volume | 12 |
| creator | Ajdukiewicz, A. B. Grainger, J. Scheuer, P. J. Sherlock, S. |
| description | Twenty-one patients treated for depression with iprindole developed evidence of liver damage: 15 were jaundiced, five had bilirubinuria, and one had pruritus. These complications occurred between four and 21 days after initial exposure to the drug. All patients recovered. Light and electron microscopic findings in liver biopsies of one of these patients were those of cholestasis without inflammation. |
| doi_str_mv | 10.1136/gut.12.9.705 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1411804</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3969911891</sourcerecordid><originalsourceid>FETCH-LOGICAL-b477t-f3aff4c7edd45ba36d062b73c10aa19a74bacb74196d633287991fd1bade73f3</originalsourceid><addsrcrecordid>eNp9kMFLwzAUxoMoc05vXjwIAw9ebM1r0rzmIsjQqYwJMoa3kDapdm7tTFvR_95Ix9CLp3f4fnzvx0fIMdAQgInLl7YJIQpliDTeIX3gIglYlCS7pE8pYBAjl_vkoK4XlNIkkdAjPQ5UxBH0ycmDbktTZHZoWjtsqmGxdkVpqqU9JHu5Xtb2aHMHZHZ7MxvdBZPH8f3oehKkHLEJcqbznGdojeFxqpkwVEQpsgyo1iA18lRnKXKQwgjmvVBKyA2k2lhkORuQq6523aYrazJbNk4vlbdYafelKl2ov0lZvKqX6kMBB0go9wVnmwJXvbe2btSial3plRUgUsplnESeuuiozFV17Wy-_QBU_cyo_IwKIiWVn9Hjp7-ttvBmN58HXV7Ujf3cxtq9KYEMYzWdj9R8OuPPT8jV2PPnHZ-uFv9__gaKcIla</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1770049582</pqid></control><display><type>article</type><title>Jaundice due to iprindole</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Ajdukiewicz, A. B. ; Grainger, J. ; Scheuer, P. J. ; Sherlock, S.</creator><creatorcontrib>Ajdukiewicz, A. B. ; Grainger, J. ; Scheuer, P. J. ; Sherlock, S.</creatorcontrib><description>Twenty-one patients treated for depression with iprindole developed evidence of liver damage: 15 were jaundiced, five had bilirubinuria, and one had pruritus. These complications occurred between four and 21 days after initial exposure to the drug. All patients recovered. Light and electron microscopic findings in liver biopsies of one of these patients were those of cholestasis without inflammation.</description><identifier>ISSN: 0017-5749</identifier><identifier>EISSN: 1468-3288</identifier><identifier>EISSN: 1458-3288</identifier><identifier>DOI: 10.1136/gut.12.9.705</identifier><identifier>PMID: 4106521</identifier><identifier>CODEN: GUTTAK</identifier><language>eng</language><publisher>England: BMJ Publishing Group Ltd and British Society of Gastroenterology</publisher><subject>Adult ; Alkaline Phosphatase - analysis ; Antidepressive Agents - adverse effects ; Aspartate Aminotransferases - analysis ; Bile ; Bilirubin - urine ; Biopsy ; Cell Nucleus ; Cholestasis - pathology ; Cholesterol - analysis ; Female ; Humans ; Indoles - adverse effects ; Jaundice - chemically induced ; Liver - pathology ; Male ; Microscopy, Electron ; Middle Aged ; Pruritus - chemically induced ; Staining and Labeling</subject><ispartof>Gut, 1971-09, Vol.12 (9), p.705-708</ispartof><rights>Copyright BMJ Publishing Group LTD Sep 1971</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b477t-f3aff4c7edd45ba36d062b73c10aa19a74bacb74196d633287991fd1bade73f3</citedby><cites>FETCH-LOGICAL-b477t-f3aff4c7edd45ba36d062b73c10aa19a74bacb74196d633287991fd1bade73f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1411804/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1411804/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4106521$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ajdukiewicz, A. B.</creatorcontrib><creatorcontrib>Grainger, J.</creatorcontrib><creatorcontrib>Scheuer, P. J.</creatorcontrib><creatorcontrib>Sherlock, S.</creatorcontrib><title>Jaundice due to iprindole</title><title>Gut</title><addtitle>Gut</addtitle><description>Twenty-one patients treated for depression with iprindole developed evidence of liver damage: 15 were jaundiced, five had bilirubinuria, and one had pruritus. These complications occurred between four and 21 days after initial exposure to the drug. All patients recovered. Light and electron microscopic findings in liver biopsies of one of these patients were those of cholestasis without inflammation.</description><subject>Adult</subject><subject>Alkaline Phosphatase - analysis</subject><subject>Antidepressive Agents - adverse effects</subject><subject>Aspartate Aminotransferases - analysis</subject><subject>Bile</subject><subject>Bilirubin - urine</subject><subject>Biopsy</subject><subject>Cell Nucleus</subject><subject>Cholestasis - pathology</subject><subject>Cholesterol - analysis</subject><subject>Female</subject><subject>Humans</subject><subject>Indoles - adverse effects</subject><subject>Jaundice - chemically induced</subject><subject>Liver - pathology</subject><subject>Male</subject><subject>Microscopy, Electron</subject><subject>Middle Aged</subject><subject>Pruritus - chemically induced</subject><subject>Staining and Labeling</subject><issn>0017-5749</issn><issn>1468-3288</issn><issn>1458-3288</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1971</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kMFLwzAUxoMoc05vXjwIAw9ebM1r0rzmIsjQqYwJMoa3kDapdm7tTFvR_95Ix9CLp3f4fnzvx0fIMdAQgInLl7YJIQpliDTeIX3gIglYlCS7pE8pYBAjl_vkoK4XlNIkkdAjPQ5UxBH0ycmDbktTZHZoWjtsqmGxdkVpqqU9JHu5Xtb2aHMHZHZ7MxvdBZPH8f3oehKkHLEJcqbznGdojeFxqpkwVEQpsgyo1iA18lRnKXKQwgjmvVBKyA2k2lhkORuQq6523aYrazJbNk4vlbdYafelKl2ov0lZvKqX6kMBB0go9wVnmwJXvbe2btSial3plRUgUsplnESeuuiozFV17Wy-_QBU_cyo_IwKIiWVn9Hjp7-ttvBmN58HXV7Ujf3cxtq9KYEMYzWdj9R8OuPPT8jV2PPnHZ-uFv9__gaKcIla</recordid><startdate>19710901</startdate><enddate>19710901</enddate><creator>Ajdukiewicz, A. B.</creator><creator>Grainger, J.</creator><creator>Scheuer, P. J.</creator><creator>Sherlock, S.</creator><general>BMJ Publishing Group Ltd and British Society of Gastroenterology</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>5PM</scope></search><sort><creationdate>19710901</creationdate><title>Jaundice due to iprindole</title><author>Ajdukiewicz, A. B. ; Grainger, J. ; Scheuer, P. J. ; Sherlock, S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b477t-f3aff4c7edd45ba36d062b73c10aa19a74bacb74196d633287991fd1bade73f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1971</creationdate><topic>Adult</topic><topic>Alkaline Phosphatase - analysis</topic><topic>Antidepressive Agents - adverse effects</topic><topic>Aspartate Aminotransferases - analysis</topic><topic>Bile</topic><topic>Bilirubin - urine</topic><topic>Biopsy</topic><topic>Cell Nucleus</topic><topic>Cholestasis - pathology</topic><topic>Cholesterol - analysis</topic><topic>Female</topic><topic>Humans</topic><topic>Indoles - adverse effects</topic><topic>Jaundice - chemically induced</topic><topic>Liver - pathology</topic><topic>Male</topic><topic>Microscopy, Electron</topic><topic>Middle Aged</topic><topic>Pruritus - chemically induced</topic><topic>Staining and Labeling</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ajdukiewicz, A. B.</creatorcontrib><creatorcontrib>Grainger, J.</creatorcontrib><creatorcontrib>Scheuer, P. J.</creatorcontrib><creatorcontrib>Sherlock, S.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Gut</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ajdukiewicz, A. B.</au><au>Grainger, J.</au><au>Scheuer, P. J.</au><au>Sherlock, S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Jaundice due to iprindole</atitle><jtitle>Gut</jtitle><addtitle>Gut</addtitle><date>1971-09-01</date><risdate>1971</risdate><volume>12</volume><issue>9</issue><spage>705</spage><epage>708</epage><pages>705-708</pages><issn>0017-5749</issn><eissn>1468-3288</eissn><eissn>1458-3288</eissn><coden>GUTTAK</coden><abstract>Twenty-one patients treated for depression with iprindole developed evidence of liver damage: 15 were jaundiced, five had bilirubinuria, and one had pruritus. These complications occurred between four and 21 days after initial exposure to the drug. All patients recovered. Light and electron microscopic findings in liver biopsies of one of these patients were those of cholestasis without inflammation.</abstract><cop>England</cop><pub>BMJ Publishing Group Ltd and British Society of Gastroenterology</pub><pmid>4106521</pmid><doi>10.1136/gut.12.9.705</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0017-5749 |
| ispartof | Gut, 1971-09, Vol.12 (9), p.705-708 |
| issn | 0017-5749 1468-3288 1458-3288 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1411804 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Adult Alkaline Phosphatase - analysis Antidepressive Agents - adverse effects Aspartate Aminotransferases - analysis Bile Bilirubin - urine Biopsy Cell Nucleus Cholestasis - pathology Cholesterol - analysis Female Humans Indoles - adverse effects Jaundice - chemically induced Liver - pathology Male Microscopy, Electron Middle Aged Pruritus - chemically induced Staining and Labeling |
| title | Jaundice due to iprindole |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-11T09%3A13%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Jaundice%20due%20to%20iprindole&rft.jtitle=Gut&rft.au=Ajdukiewicz,%20A.%20B.&rft.date=1971-09-01&rft.volume=12&rft.issue=9&rft.spage=705&rft.epage=708&rft.pages=705-708&rft.issn=0017-5749&rft.eissn=1468-3288&rft.coden=GUTTAK&rft_id=info:doi/10.1136/gut.12.9.705&rft_dat=%3Cproquest_pubme%3E3969911891%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1770049582&rft_id=info:pmid/4106521&rfr_iscdi=true |