Jaundice due to iprindole

Twenty-one patients treated for depression with iprindole developed evidence of liver damage: 15 were jaundiced, five had bilirubinuria, and one had pruritus. These complications occurred between four and 21 days after initial exposure to the drug. All patients recovered. Light and electron microsco...

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Veröffentlicht in:	Gut 1971-09, Vol.12 (9), p.705-708
Hauptverfasser:	Ajdukiewicz, A. B., Grainger, J., Scheuer, P. J., Sherlock, S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Alkaline Phosphatase - analysis Antidepressive Agents - adverse effects Aspartate Aminotransferases - analysis Bile Bilirubin - urine Biopsy Cell Nucleus Cholestasis - pathology Cholesterol - analysis Female Humans Indoles - adverse effects Jaundice - chemically induced Liver - pathology Male Microscopy, Electron Middle Aged Pruritus - chemically induced Staining and Labeling
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Beschreibung
Zusammenfassung:	Twenty-one patients treated for depression with iprindole developed evidence of liver damage: 15 were jaundiced, five had bilirubinuria, and one had pruritus. These complications occurred between four and 21 days after initial exposure to the drug. All patients recovered. Light and electron microscopic findings in liver biopsies of one of these patients were those of cholestasis without inflammation.
ISSN:	0017-5749 1468-3288 1458-3288
DOI:	10.1136/gut.12.9.705