The effect of route of injection upon the development of circulating antibody in response to a variety of antigens
Ovalbumin, Escherichia coli lipopolysaccharide, and a combination of metabolic and somatic antigens of Haemonchus contortus were injected into rabbits via the intravenous, intramuscular, intradermal and intraperitoneal routes. Haemagglutination titres were obtained on untreated sera and sera after r...
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| Veröffentlicht in: | Immunology 1968-06, Vol.14 (6), p.781-785 |
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| container_title | Immunology |
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| creator | Schelling, M E Silverman, P H |
| description | Ovalbumin,
Escherichia coli
lipopolysaccharide, and a combination of metabolic and somatic antigens of
Haemonchus contortus
were injected into rabbits via the intravenous, intramuscular, intradermal and intraperitoneal routes. Haemagglutination titres were obtained on untreated sera and sera after reduction and alkylation. The data suggest that the route of injection most efficient in stimulating the production of circulating antibody would depend upon whether the antigen in question elicits 19S globulin, 7S globulin or a combination of the two either in the form of sequential synthesis or a prolonged response of both types of immunoglobulins. |
| format | Article |
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Escherichia coli
lipopolysaccharide, and a combination of metabolic and somatic antigens of
Haemonchus contortus
were injected into rabbits via the intravenous, intramuscular, intradermal and intraperitoneal routes. Haemagglutination titres were obtained on untreated sera and sera after reduction and alkylation. The data suggest that the route of injection most efficient in stimulating the production of circulating antibody would depend upon whether the antigen in question elicits 19S globulin, 7S globulin or a combination of the two either in the form of sequential synthesis or a prolonged response of both types of immunoglobulins.</description><identifier>ISSN: 0019-2805</identifier><identifier>EISSN: 1365-2567</identifier><identifier>PMID: 4873831</identifier><language>eng</language><publisher>England</publisher><subject>Animals ; Antibody Formation ; Antigens ; Escherichia coli - immunology ; Hemagglutination Tests ; Immunization ; Immunoglobulin G - analysis ; Immunoglobulin M - analysis ; Injections, Intradermal ; Injections, Intramuscular ; Injections, Intraperitoneal ; Injections, Intravenous ; Lipopolysaccharides - administration & dosage ; Mercaptoethanol ; Ovalbumin - administration & dosage ; Rabbits ; Trichostrongyloidea - immunology</subject><ispartof>Immunology, 1968-06, Vol.14 (6), p.781-785</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1409372/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1409372/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4873831$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schelling, M E</creatorcontrib><creatorcontrib>Silverman, P H</creatorcontrib><title>The effect of route of injection upon the development of circulating antibody in response to a variety of antigens</title><title>Immunology</title><addtitle>Immunology</addtitle><description>Ovalbumin,
Escherichia coli
lipopolysaccharide, and a combination of metabolic and somatic antigens of
Haemonchus contortus
were injected into rabbits via the intravenous, intramuscular, intradermal and intraperitoneal routes. Haemagglutination titres were obtained on untreated sera and sera after reduction and alkylation. The data suggest that the route of injection most efficient in stimulating the production of circulating antibody would depend upon whether the antigen in question elicits 19S globulin, 7S globulin or a combination of the two either in the form of sequential synthesis or a prolonged response of both types of immunoglobulins.</description><subject>Animals</subject><subject>Antibody Formation</subject><subject>Antigens</subject><subject>Escherichia coli - immunology</subject><subject>Hemagglutination Tests</subject><subject>Immunization</subject><subject>Immunoglobulin G - analysis</subject><subject>Immunoglobulin M - analysis</subject><subject>Injections, Intradermal</subject><subject>Injections, Intramuscular</subject><subject>Injections, Intraperitoneal</subject><subject>Injections, Intravenous</subject><subject>Lipopolysaccharides - administration & dosage</subject><subject>Mercaptoethanol</subject><subject>Ovalbumin - administration & dosage</subject><subject>Rabbits</subject><subject>Trichostrongyloidea - immunology</subject><issn>0019-2805</issn><issn>1365-2567</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1968</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVUFtLwzAUDqLMOf0JQp58KyRt0zQvggxvIPgyn0sup1tGl9QkHezfm-kQfTnX73I4Z2hOq4YVJWv4OZoTQkVRtoRdoqsYt7mtCGMzNKtbXrUVnaOw2gCGvgedsO9x8FOCY2HdNo-sd3gac0gZZWAPgx934L6h2gY9DTJZt8bSJau8OWQaDhAzIwJOHku8l8FCOhwJR9AaXLxGF70cItyc8gJ9PD2uli_F2_vz6_LhrRjLhqaCcUYaxUDS1kCjWsGZpgo0CMO5qXgJbam0LKWRwjRcM8JBgBK0rAVX1FQLdP-jO05qB0bnu4McujHYnQyHzkvb_d84u-nWft_RmoisnwXuTgLBf04QU7ezUcMwSAd-il1bC8IJqTPw9q_Tr8Xpy9UXLYp9mA</recordid><startdate>196806</startdate><enddate>196806</enddate><creator>Schelling, M E</creator><creator>Silverman, P H</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>196806</creationdate><title>The effect of route of injection upon the development of circulating antibody in response to a variety of antigens</title><author>Schelling, M E ; Silverman, P H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p261t-57506b5ea18de6b8975c1bece9d77d372e82bca2ada9d67c507e9eb912497b1d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1968</creationdate><topic>Animals</topic><topic>Antibody Formation</topic><topic>Antigens</topic><topic>Escherichia coli - immunology</topic><topic>Hemagglutination Tests</topic><topic>Immunization</topic><topic>Immunoglobulin G - analysis</topic><topic>Immunoglobulin M - analysis</topic><topic>Injections, Intradermal</topic><topic>Injections, Intramuscular</topic><topic>Injections, Intraperitoneal</topic><topic>Injections, Intravenous</topic><topic>Lipopolysaccharides - administration & dosage</topic><topic>Mercaptoethanol</topic><topic>Ovalbumin - administration & dosage</topic><topic>Rabbits</topic><topic>Trichostrongyloidea - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schelling, M E</creatorcontrib><creatorcontrib>Silverman, P H</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schelling, M E</au><au>Silverman, P H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of route of injection upon the development of circulating antibody in response to a variety of antigens</atitle><jtitle>Immunology</jtitle><addtitle>Immunology</addtitle><date>1968-06</date><risdate>1968</risdate><volume>14</volume><issue>6</issue><spage>781</spage><epage>785</epage><pages>781-785</pages><issn>0019-2805</issn><eissn>1365-2567</eissn><abstract>Ovalbumin,
Escherichia coli
lipopolysaccharide, and a combination of metabolic and somatic antigens of
Haemonchus contortus
were injected into rabbits via the intravenous, intramuscular, intradermal and intraperitoneal routes. Haemagglutination titres were obtained on untreated sera and sera after reduction and alkylation. The data suggest that the route of injection most efficient in stimulating the production of circulating antibody would depend upon whether the antigen in question elicits 19S globulin, 7S globulin or a combination of the two either in the form of sequential synthesis or a prolonged response of both types of immunoglobulins.</abstract><cop>England</cop><pmid>4873831</pmid><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0019-2805 |
| ispartof | Immunology, 1968-06, Vol.14 (6), p.781-785 |
| issn | 0019-2805 1365-2567 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1409372 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Animals Antibody Formation Antigens Escherichia coli - immunology Hemagglutination Tests Immunization Immunoglobulin G - analysis Immunoglobulin M - analysis Injections, Intradermal Injections, Intramuscular Injections, Intraperitoneal Injections, Intravenous Lipopolysaccharides - administration & dosage Mercaptoethanol Ovalbumin - administration & dosage Rabbits Trichostrongyloidea - immunology |
| title | The effect of route of injection upon the development of circulating antibody in response to a variety of antigens |
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