A comparison of the amounts and the antigenicity of polymeric materials formed in aqueous solution by some beta-lactam antibiotics

A comparison of the amounts and the antigenicity of polymeric materials formed in aqueous solution by some beta-lactam antibiotics

Concentrated aqueous solutions of some β-lactam antibiotics were stored for 14 days. Samples were then subjected to gel filtration and fractions in the high molecular weight regions of the eluate were collected and lyophilized. The yields of materials from solutions of various β-lactam antibiotics w...

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Veröffentlicht in:Immunology 1971-09, Vol.21 (3), p.527-533
Hauptverfasser: Smith, H, Dewdney, J M, Wheeler, A W
Format: Artikel
Sprache:eng
Schlagworte:
Ampicillin
Animals
Antibodies
Carbenicillin
Chromatography, Gel
Guinea Pigs
Immune Sera
Molecular Weight
Passive Cutaneous Anaphylaxis
Penicillin G
Penicillins
Polymers
Rabbits
Solutions
Water
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Zusammenfassung:Concentrated aqueous solutions of some β-lactam antibiotics were stored for 14 days. Samples were then subjected to gel filtration and fractions in the high molecular weight regions of the eluate were collected and lyophilized. The yields of materials from solutions of various β-lactam antibiotics were compared and the antigenicity of the materials was assessed by their ability to react with antibodies of benzylpenicilloyl specificity raised in rabbits and tested in guinea-pigs by passive cutaneous anaphylaxis.
ISSN:0019-2805
1365-2567