Bursal origin of bone marrow cells with competence for antibody formation

Bursal origin of bone marrow cells with competence for antibody formation

The impaired antibody response of neonatally bursectomized chickens was restored by bone marrow cells from normal—but not from bursectomized—syngeneic donors. Chimaerism of donor cells in the recipients was demonstrated using the sex chromosomal marker. Attempts to substitute autologous bursal cell...

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Veröffentlicht in:Immunology 1972-07, Vol.23 (1), p.107-111
Hauptverfasser: Ivanyi, J, Murgatroyd, L B, Lydyard, P M
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Animals, Newborn
Antibody Formation
Antibody-Producing Cells
Bone Marrow - immunology
Bone Marrow Cells
Bone Marrow Transplantation
Brief Communications
Bursa of Fabricius - immunology
Bursa of Fabricius - transplantation
Chickens
Female
Injections, Intravenous
Male
Mitosis
Mosaicism
Sex Chromosomes
Spleen - cytology
Transplantation, Homologous
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Zusammenfassung:The impaired antibody response of neonatally bursectomized chickens was restored by bone marrow cells from normal—but not from bursectomized—syngeneic donors. Chimaerism of donor cells in the recipients was demonstrated using the sex chromosomal marker. Attempts to substitute autologous bursal cell suspensions for the bursa in situ were unsuccessful. It is concluded that B lymphocytes in chicken bone marrow have matured in the bursa.
ISSN:0019-2805
1365-2567