Pharmacokinetic profile of indoprofen in elderly subjects

Multiple dosing four times daily for 7 days of indoprofen 200 mg, a non‐ steroidal anti‐inflammatory drug with a short half‐life (t1/2), revealed drug accumulation in eight elderly subjects. This indicates a substantially longer t1/2 (11 h) than that reported in young persons (3 h). A reduction in d...

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Veröffentlicht in:British journal of clinical pharmacology 1986-12, Vol.22 (6), p.721-724
Hauptverfasser: Lund, B, Egsmose, C, Knudsen, O, Andersen, RB
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creator Lund, B
Egsmose, C
Knudsen, O
Andersen, RB
description Multiple dosing four times daily for 7 days of indoprofen 200 mg, a non‐ steroidal anti‐inflammatory drug with a short half‐life (t1/2), revealed drug accumulation in eight elderly subjects. This indicates a substantially longer t1/2 (11 h) than that reported in young persons (3 h). A reduction in dose compared to younger subjects is recommended in elderly patients with osteoarthritis.
doi_str_mv 10.1111/j.1365-2125.1986.tb02964.x
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source MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection
subjects Aged
Biological and medical sciences
Bones, joints and connective tissue. Antiinflammatory agents
Female
Half-Life
Humans
Indoprofen - blood
Indoprofen - metabolism
Indoprofen - therapeutic use
Kinetics
Male
Medical sciences
Middle Aged
Osteoarthritis - drug therapy
Pharmacology. Drug treatments
Phenylpropionates - metabolism
title Pharmacokinetic profile of indoprofen in elderly subjects
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