Cortisol does not inhibit prednisolone clearance

The disposition of prednisolone has been studied in eight male subjects with and without the concomitant administration of cortisol which produced plasma cortisol concentrations 10‐fold higher than endogenous levels. The clearance and steady‐state distribution volume of total prednisolone were incre...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	British journal of clinical pharmacology 1985-10, Vol.20 (4), p.414-416
Hauptverfasser:	Meffin, PJ, Sallustio, BC, Purdie, YJ, Robson, RA, Wing, LM, Brooks, PM
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Humans Hydrocortisone - blood Hydrocortisone - pharmacology Kinetics Male Medical sciences Pharmacology. Drug treatments Prednisolone - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The disposition of prednisolone has been studied in eight male subjects with and without the concomitant administration of cortisol which produced plasma cortisol concentrations 10‐fold higher than endogenous levels. The clearance and steady‐state distribution volume of total prednisolone were increased as was the prednisolone free fraction but the clearance of unbound prednisolone was unaltered by cortisol co‐ administration.
ISSN:	0306-5251 1365-2125
DOI:	10.1111/j.1365-2125.1985.tb05087.x