Anticipatory evolution and DNA shuffling

Anticipatory evolution and DNA shuffling

DNA shuffling has proven to be a powerful technique for the directed evolution of proteins. A mix of theoretical and applied research has now provided insights into how recombination can be guided to more efficiently generate proteins and even organisms with altered functions.

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Veröffentlicht in:Genome Biology (Online Edition) 2002-07, Vol.3 (8), p.REVIEWS1021-reviews1021
Hauptverfasser: Bacher, Jamie M, Reiss, Brian D, Ellington, Andrew D
Format: Artikel
Sprache:eng
Schlagworte:
DNA
DNA - genetics
Evolution, Molecular
Genetic code
Genomes
Genomics
Minireview
Proteins
Recombination, Genetic - genetics
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Beschreibung
Zusammenfassung:DNA shuffling has proven to be a powerful technique for the directed evolution of proteins. A mix of theoretical and applied research has now provided insights into how recombination can be guided to more efficiently generate proteins and even organisms with altered functions.
ISSN:1474-760X
1465-6906
1474-760X
1465-6914
DOI:10.1186/gb-2002-3-8-reviews1021