De novo Designed Peptide-Based Amyloid Fibrils

Identification of therapeutic strategies to prevent or cure diseases associated with amyloid fibril deposition in tissue (Alzheimer's disease, spongiform encephalopathies, etc.) requires a rational understanding of the driving forces involved in the formation of these organized assemblies rich...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2002-12, Vol.99 (25), p.16052-16057
Hauptverfasser:	de la Paz, Manuela López, Goldie, Kenneth, Zurdo, Jesús, Lacroix, Emmanuel, Dobson, Christopher M., Hoenger, Andreas, Serrano, Luis
Format:	Artikel
Sprache:	eng
Schlagworte:	Aggregation Algorithms Amino Acid Sequence Amino acids Amyloid - chemical synthesis Amyloid - chemistry Amyloids Biological Sciences Biophysics Circular Dichroism Computer-Aided Design Histological shadowing Microscopy, Electron Models, Molecular Molecular structure Molecules Neurology Oligopeptides - chemical synthesis Oligopeptides - chemistry Peptides Polymerization Protein Folding Protein Structure, Secondary Solar fibrils Static Electricity Thermodynamics Wave diffraction X-Ray Diffraction
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