Interferon-gamma as an adjuvant in immunocompromised mice

We have compared interferon-gamma (IFN-gamma) with saponin and interleukin-1 (IL-1) as adjuvants for a blood-stage malaria vaccine in mice with various immunological abnormalities. IFN-gamma was particularly effective in Biozzi low antibody responder mice, mice selectively bred to produce antibody o...

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Veröffentlicht in:	Immunology 1989-08, Vol.67 (4), p.520-524
Hauptverfasser:	HEATH, A. W, DEVEY, M. E, BROWN, I. N, RICHARDS, C. E, PLAYFAIR, J. H. L
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic Animals Antibody Affinity Applied microbiology Biological and medical sciences Female Fundamental and applied biological sciences. Psychology Immunologic Deficiency Syndromes - immunology Interferon-gamma - immunology Lymphocyte Depletion Male Mice Microbiology Recombinant Proteins T-Lymphocytes Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
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Zusammenfassung:	We have compared interferon-gamma (IFN-gamma) with saponin and interleukin-1 (IL-1) as adjuvants for a blood-stage malaria vaccine in mice with various immunological abnormalities. IFN-gamma was particularly effective in Biozzi low antibody responder mice, mice selectively bred to produce antibody of low affinity, and mice depleted of CD4+ T cells. IFN-gamma and other cytokines may be safe adjuvants for use in human immunodeficiency states.
ISSN:	0019-2805 1365-2567