A Comprehensive Linkage Analysis of Chromosome 21q22 Supports Prior Evidence for a Putative Bipolar Affective Disorder Locus

Previously, we demonstrated evidence of linkage to bipolar affective disorder (BP) in a single large, multigenerational family with a LOD score of 3.41 at the PFKL locus on chromosome 21q22.3. Additional families showed little support for linkage to PFKL under homogeneity or heterogeneity, in that s...

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Veröffentlicht in:	American journal of human genetics 1999, Vol.64 (1), p.210-217
Hauptverfasser:	Aita, Vincent M., Liu, Jianjun, Knowles, James A., Terwilliger, Joseph D., Baltazar, Romulo, Grunn, Adina, Loth, Jo Ellen, Kanyas, Kyra, Lerer, Bernard, Endicott, Jean, Wang, Zhenyuan, Penchaszadeh, Graciela, Gilliam, T. Conrad, Baron, Miron
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult and adolescent clinical studies Biological and medical sciences Bipolar affective disorder Bipolar Disorder - genetics Bipolar disorders Chromosome 21q22 Chromosome Mapping Chromosomes, Human, Pair 21 Genetic Linkage Genetic Markers Genotype Humans Linkage analysis Lod Score Medical sciences Mood disorders Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry
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Zusammenfassung:	Previously, we demonstrated evidence of linkage to bipolar affective disorder (BP) in a single large, multigenerational family with a LOD score of 3.41 at the PFKL locus on chromosome 21q22.3. Additional families showed little support for linkage to PFKL under homogeneity or heterogeneity, in that study. We have expanded on that analysis, with 31 microsatellite markers at an average marker spacing of ≤2 cM, in the largest multigenerational BP pedigree series reported to date. A two-point heterogeneity (α=0.5) LOD score of 3.35 ( P
ISSN:	0002-9297 1537-6605
DOI:	10.1086/302185