RNA folding at elementary step resolution

We study the stochastic folding kinetics of RNA sequences into secondary structures with a new algorithm based on the formation, dissociation, and the shifting of individual base pairs. We discuss folding mechanisms and the correlation between the barrier structure of the conformational landscape an...

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Veröffentlicht in:	RNA (Cambridge) 2000-03, Vol.6 (3), p.325-338, Article S1355838200992161
Hauptverfasser:	FLAMM, CHRISTOPH, FONTANA, WALTER, HOFACKER, IVO L., SCHUSTER, PETER
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Base Sequence Energy Transfer Kinetics Molecular Sequence Data Nucleic Acid Conformation RNA - chemistry RNA - metabolism RNA, Transfer, Phe - chemistry RNA, Transfer, Phe - metabolism Thermodynamics tRNA
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Zusammenfassung:	We study the stochastic folding kinetics of RNA sequences into secondary structures with a new algorithm based on the formation, dissociation, and the shifting of individual base pairs. We discuss folding mechanisms and the correlation between the barrier structure of the conformational landscape and the folding kinetics for a number of examples based on artificial and natural sequences, including the influence of base modification in tRNAs.
ISSN:	1355-8382 1469-9001
DOI:	10.1017/S1355838200992161