The role of calcium ions and calcium channel entry blockers in experimental ischemia-reperfusion-induced liver injury

Verapamil administered before treatment, but not after treatment, had a beneficial effect on a 90-minute warm ischemia-reperfusion rat liver injury model. The possible activation of proteases converting the xanthine dehydrogenase to xanthine oxidase, the significant mitochondrial calcium loading dur...

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Veröffentlicht in:	Annals of surgery 1991-02, Vol.213 (2), p.137-142
Hauptverfasser:	NAUTA, R. J, TSIMOYIANNIS, E, URIBE, M, WALSH, D. B, MILLER, D, BUTTERFIELD, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine Transaminase - blood Alkaline Phosphatase - blood Animals Aspartate Aminotransferases - blood Biological and medical sciences Calcium - pharmacology Digestive system L-Iditol 2-Dehydrogenase - blood L-Lactate Dehydrogenase - blood Liver - blood supply Liver - enzymology Liver - pathology Medical sciences Pharmacology. Drug treatments Rats Rats, Inbred Strains Reperfusion Injury - metabolism Reperfusion Injury - pathology Verapamil - pharmacology
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Zusammenfassung:	Verapamil administered before treatment, but not after treatment, had a beneficial effect on a 90-minute warm ischemia-reperfusion rat liver injury model. The possible activation of proteases converting the xanthine dehydrogenase to xanthine oxidase, the significant mitochondrial calcium loading during the ischemic period, and the potentiation of calcium and oxygen-derived free radicals to promote injury to mitochondria are mechanisms supported by this study, based on both histologic observations and on the pattern of enzyme leak after the acute ischemic event.
ISSN:	0003-4932 1528-1140
DOI:	10.1097/00000658-199102000-00008