NF-κB Activation in Esophageal Adenocarcinoma: Relationship to Barrett's Metaplasia, Survival, and Response to Neoadjuvant Chemoradiotherapy

Esophageal adenocarcinoma tumor tissues contain high levels of activated nuclear factor kappa-B (NF-κB), and the absence of NF-κB in esophageal cancer correlates with the early stage of the disease and with responsiveness to neoadjuvant therapy. Exposure of esophageal cancer cells to deoxycholic acid or low pH induced NF-κB expression.