Expression of cellular FLICE inhibitory proteins (cFLIP) in normal and traumatic murine and human cerebral cortex

Cellular Fas-associated death domain-like interleukin-1-beta converting enzyme (FLICE) inhibitory proteins (cFLIPs) are endogenous caspase homologues that inhibit programmed cell death. We hypothesized that cFLIPs are differentially expressed in response to traumatic brain injury (TBI). cFLIP-alpha...

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Veröffentlicht in:	Journal of Cerebral Blood Flow & Metabolism 2005-08, Vol.25 (8), p.1030-1040
Hauptverfasser:	Hainsworth, Atticus H, Bermpohl, Daniela, Webb, Tania E, Darwish, Ribal, Fiskum, Gary, Qiu, Jianhua, McCarthy, Deirdre, Moskowitz, Michael A, Whalen, Michael J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Animals Biological and medical sciences Blotting, Western Brain Chemistry - physiology Brain Injuries - metabolism CASP8 and FADD-Like Apoptosis Regulating Protein Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges Cerebral Cortex - injuries Cerebral Cortex - metabolism DNA, Complementary - biosynthesis DNA, Complementary - genetics Female Fundamental and applied biological sciences. Psychology Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Humans Immunohistochemistry In Situ Nick-End Labeling Indicators and Reagents Intracellular Signaling Peptides and Proteins - metabolism Isomerism Male Medical sciences Mice Mice, Inbred C57BL Middle Aged Nervous system (semeiology, syndromes) Neurology Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - biosynthesis Vascular diseases and vascular malformations of the nervous system Vertebrates: nervous system and sense organs
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Zusammenfassung:	Cellular Fas-associated death domain-like interleukin-1-beta converting enzyme (FLICE) inhibitory proteins (cFLIPs) are endogenous caspase homologues that inhibit programmed cell death. We hypothesized that cFLIPs are differentially expressed in response to traumatic brain injury (TBI). cFLIP-alpha and cFLIP-delta mRNA were expressed in normal mouse brain—specifically cFLIP-delta (but not cFLIP-alpha) protein was robustly expressed. After controlled cortical impact (CCI), cFLIP-alpha expression increased initially then decreased to control levels at 12 h, increasing again at 24-72 h (P
ISSN:	0271-678X 1559-7016
DOI:	10.1038/sj.jcbfm.9600104