The tripartite motif family identifies cell compartments

A functional genomic approach, based on systematic data gathering, was used to characterize a family of proteins containing a tri partite m otif (TRIM). A total of 37 TRIM genes/proteins were studied, 21 of which were novel. The results demonstrate that TRIM proteins share a common function: by mean...

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Veröffentlicht in:	The EMBO journal 2001-05, Vol.20 (9), p.2140-2151
Hauptverfasser:	Reymond, Alexandre, Meroni, Germana, Fantozzi, Anna, Merla, Giuseppe, Cairo, Stefano, Luzi, Lucilla, Riganelli, Daniela, Zanaria, Elena, Messali, Silvia, Cainarca, Silvia, Guffanti, Alessandro, Minucci, Saverio, Pelicci, Pier Giuseppe, Ballabio, Andrea
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Motifs - physiology Animals Blotting, Northern Carrier Proteins cell compartmentalization Cell Compartmentation - physiology Cell Line Chromosome Mapping Cloning, Molecular Databases, Factual Embryo, Mammalian functional genomics Humans In Situ Hybridization Mice Molecular Sequence Data Multigene Family - genetics Mutagenesis, Site-Directed Nerve Tissue Proteins nuclear bodies Organ Specificity Protein Binding - physiology Protein Structure, Tertiary - physiology Proteins - physiology RBCC Sequence Homology, Amino Acid Subcellular Fractions - metabolism tripartite motif Two-Hybrid System Techniques Ubiquitin-Protein Ligases
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Beschreibung
Zusammenfassung:	A functional genomic approach, based on systematic data gathering, was used to characterize a family of proteins containing a tri partite m otif (TRIM). A total of 37 TRIM genes/proteins were studied, 21 of which were novel. The results demonstrate that TRIM proteins share a common function: by means of homo‐multimerization they identify specific cell compartments.
ISSN:	0261-4189 1460-2075 1460-2075
DOI:	10.1093/emboj/20.9.2140