Key stages of mammary gland development: molecular mechanisms involved in the formation of the embryonic mammary gland

The development of the embryonic mammary gland involves communication between the epidermis and mesenchyme and is coordinated temporally and spatially by various signaling pathways. Although many more genes are likely to control mammary gland development, functional roles have been identified for Wn...

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Veröffentlicht in:	Breast cancer research : BCR 2005-01, Vol.7 (5), p.220-224, Article 220
Hauptverfasser:	Hens, Julie R, Wysolmerski, John J
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Breast - embryology Breast - growth & development Embryonic Development Epidermal Cells Epidermis - physiology Female Fibroblast growth factors Humans Lactation Mammary Glands, Animal - embryology Mammary Glands, Animal - growth & development Mesoderm - cytology Mesoderm - physiology Mice Milk - metabolism Morphogenesis Parathyroid Hormone-Related Protein - physiology Review
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Beschreibung
Zusammenfassung:	The development of the embryonic mammary gland involves communication between the epidermis and mesenchyme and is coordinated temporally and spatially by various signaling pathways. Although many more genes are likely to control mammary gland development, functional roles have been identified for Wnt, fibroblast growth factor, and parathyroid hormone-related protein signaling. This review describes what is known about the molecular mechanisms that regulate embryonic mammary gland development.
ISSN:	1465-542X 1465-5411 1465-542X
DOI:	10.1186/bcr1306