A New Mutator Phenotype in Breast Cancer?

Scientists now understand that the development of a cell from normal to tumorigenic involves a sequence of mutational and chromosonal events. The increased frequency of transversions in the breast tumors of mice may be caused by a mechanism other than oxidative damage.

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Bibliographische Detailangaben
Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2002-03, Vol.99 (6), p.3368-3369
1. Verfasser:	de Boer, Johan G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Breast cancer Cancer Carcinogenesis Cell Transformation, Neoplastic - genetics Commentaries DNA DNA damage DNA Damage - genetics DNA Repair - genetics Female Genes Genetic mutation Mammary Neoplasms, Animal - enzymology Mammary Neoplasms, Animal - genetics Medical research Mice Mutagenesis - genetics Mutation Phenotype Phenotypes Receptor, ErbB-2 - genetics Receptor, ErbB-2 - metabolism Receptors Tumors
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Beschreibung
Zusammenfassung:	Scientists now understand that the development of a cell from normal to tumorigenic involves a sequence of mutational and chromosonal events. The increased frequency of transversions in the breast tumors of mice may be caused by a mechanism other than oxidative damage.
ISSN:	0027-8424 1091-6490
DOI:	10.1073/pnas.082095799