Role of connective tissue growth factor in the pathogenesis of diabetic nephropathy

We characterized a rabbit polyclonal antibody raised against human recombinant connective tissue growth factor (CTGF). The antibody recognised a higher molecular mass form (approx. 56 kDa) of CTGF in mesangial cell lysates as well as the monomeric (36-38 kDa) and lower molecular mass forms (

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Bibliographische Detailangaben
Veröffentlicht in:	Biochemical journal 2001-10, Vol.359 (Pt 1), p.77-87
Hauptverfasser:	Wahab, N A, Yevdokimova, N, Weston, B S, Roberts, T, Li, X J, Brinkman, H, Mason, R M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biopsy Blotting, Western Cells, Cultured Cloning, Molecular Connective Tissue Growth Factor Diabetes Mellitus, Experimental - etiology Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Experimental - pathology Diabetic Nephropathies - etiology Diabetic Nephropathies - metabolism Diabetic Nephropathies - pathology DNA, Complementary Enzyme-Linked Immunosorbent Assay Fibronectins - metabolism Gene Expression Regulation - drug effects Glomerular Mesangium - metabolism Glomerular Mesangium - pathology Glucose - metabolism Glucose - pharmacology Humans Immediate-Early Proteins - physiology Immunoenzyme Techniques Immunoglobulin G - pharmacology Intercellular Signaling Peptides and Proteins - physiology Kidney - metabolism Mice Mice, Inbred NOD Oligonucleotides, Antisense - pharmacology Plasminogen Activator Inhibitor 1 - metabolism Recombinant Fusion Proteins - metabolism RNA, Messenger Transfection Transforming Growth Factor beta - metabolism Transforming Growth Factor beta1
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Beschreibung
Zusammenfassung:	We characterized a rabbit polyclonal antibody raised against human recombinant connective tissue growth factor (CTGF). The antibody recognised a higher molecular mass form (approx. 56 kDa) of CTGF in mesangial cell lysates as well as the monomeric (36-38 kDa) and lower molecular mass forms (
ISSN:	0264-6021 1470-8728
DOI:	10.1042/0264-6021:3590077