The chemical mechanism of beta-haematin formation studied by Mössbauer spectroscopy

Spontaneous formation of beta-haematin (malaria pigment) from haematin in acetate solution follows pseudo-zero-order and not autocatalytic kinetics. Acetate appears to facilitate the reaction by solubilizing the haematin and acting as a phase-transfer catalyst, a role which, in vivo, could be fulfil...

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Veröffentlicht in:	Biochemical journal 1996-08, Vol.318 ( Pt 1) (1), p.25-27
Hauptverfasser:	Adams, P A, Egan, T J, Ross, D C, Silver, J, Marsh, P J
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetates - chemistry Animals Hemeproteins - biosynthesis Hemeproteins - chemistry Hemin - chemistry Hemin - metabolism Hydrogen-Ion Concentration Kinetics Pigments, Biological - chemistry Pigments, Biological - metabolism Plasmodium - metabolism Spectroscopy, Mossbauer
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Spontaneous formation of beta-haematin (malaria pigment) from haematin in acetate solution follows pseudo-zero-order and not autocatalytic kinetics. Acetate appears to facilitate the reaction by solubilizing the haematin and acting as a phase-transfer catalyst, a role which, in vivo, could be fulfilled by carboxylic acids or amino acids.
ISSN:	0264-6021 1470-8728
DOI:	10.1042/bj3180025