THE Ah LOCUS: BIOCHEMICAL BASIS FOR GENETIC DIFFERENCES IN BRAIN TUMOR FORMATION IN MICE

Allelic differences at the Ah locus are showen to exist in the mouse brain. This finding probably explains inbred mouse strain differences in polycyclic hydrocarbon tumorigenesis of the brain described more than 35 years ago and may be important in understanding the etiology of genetic differences i...

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Veröffentlicht in:	Genetics (Austin) 1979-08, Vol.92 (4), p.1205-1210
Hauptverfasser:	Levitt, Roy C, Fysh, Jacquelene M, Jensen, Nancy M, Nebert, Daniel W
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Animals Aryl Hydrocarbon Hydroxylases - biosynthesis Aryl Hydrocarbon Hydroxylases - genetics Brain Neoplasms - chemically induced Brain Neoplasms - genetics Chromosome Mapping Cytochrome P-450 Enzyme System - biosynthesis Cytochrome P-450 Enzyme System - genetics Enzyme Induction Genes Investigations Male Methylcholanthrene Mice Mice, Inbred Strains - genetics Neoplasms, Experimental - chemically induced Neoplasms, Experimental - genetics
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Zusammenfassung:	Allelic differences at the Ah locus are showen to exist in the mouse brain. This finding probably explains inbred mouse strain differences in polycyclic hydrocarbon tumorigenesis of the brain described more than 35 years ago and may be important in understanding the etiology of genetic differences in certain human intracranial neoplasms.
ISSN:	0016-6731 1943-2631 1943-2631
DOI:	10.1093/genetics/92.4.1205