failure of selenium supplementation to prevent copper-induced liver damage in Fischer 344 rats

This study evaluates the ability of selenium (Se) supplementation to prevent experimental copper (Cu)-induced hepatocellular damage. Weanling male Fischer 344 rats were randomly assigned to groups of 15, 3 groups (A,B,C) were fed Cu-loaded diets (containing 2000 microg/g copper, added as CuSO4) and...

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Veröffentlicht in:	Canadian journal of veterinary research 2001-04, Vol.65 (2), p.104-110
Hauptverfasser:	Aburto, E.M, Cribb, A, Fuentealba, I.C, Ikede, B.O, Kibenge, F.S.B, Markham, F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals copper Copper - metabolism Copper - toxicity dietary mineral supplements Dietary Supplements dosage enzyme activity glutathione peroxidase Glutathione Peroxidase - analysis hepatitis histochemistry Histocytochemistry - veterinary histopathology lipid peroxidation Lipid Peroxidation - drug effects liver Liver - drug effects Liver - metabolism Liver - pathology Male malondialdehyde Malondialdehyde - analysis mineral excess nutrient deficiencies nutrient-nutrient interactions Pilot Projects Random Allocation Rats Rats, Inbred F344 selenium Selenium - administration & dosage Time Factors
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