Variations in the phosphate content of histone F1 in normal and irradiated tissues

1. The capacity of the histone-DNA complex to act as a template for RNA synthesis is increased by phosphorylation of histone F1. 2. In regenerating liver, DNA synthesis is preceded by phosphorylation of histone F1. 3. Exposure to ionizing radiation in vivo decreases and delays the phosphorylation of...

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Veröffentlicht in:	Biochem. J., 110: 187-91(Nov. 1968) 110: 187-91(Nov. 1968), 1968-11, Vol.110 (2), p.187-191
Hauptverfasser:	Stevely, W S, Stocken, L A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals BIOCHEMISTRY BIOSYNTHESIS BODY Cell Division DNA DNA - biosynthesis GAMMA RADIATION GAMMA RADIATION/effects on phosphorylation of histones in kidneys and regenerating liver of rats HISTONES Histones - analysis HISTONES/radiation effects on phosphorylation of, in kidneys and regenerating liver of rats Hyperplasia IRRADIATION Kidney - analysis Kidney - radiation effects KIDNEYS KIDNEYS/ radiation effects on phosphorylation of histones in, of rats in relation to synthesis of DNA and RNA LIVER Liver - analysis Liver - radiation effects Liver Regeneration LIVER/radiation effects on phosphorylation of histones in regenerating, of rats in relation to synthesis of DNA and RNA METABOLISM N28130 -Life Sciences-Biochemistry, Physiology, & Molecular Biology-Metabolism, Physiology & Toxicology NUCLEIC ACID, DEOXYRIBO-/ radiation effects on synthesis of, in kidneys and regenerating liver of rats, relation of histone phosphorylation to NUCLEIC ACID, RIBO-/radiation effects on synthesis of, in kidneys and regenerating liver of rats, relation of histone phosphorylation to Phosphates - analysis PHOSPHORUS PROTEINS RADIATION DOSES RADIATION EFFECTS RATS REACTION KINETICS REGENERATION RIBONUCLEIC ACID RNA - biosynthesis Templates, Genetic TESTING VARIATIONS X RADIATION
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Zusammenfassung:	1. The capacity of the histone-DNA complex to act as a template for RNA synthesis is increased by phosphorylation of histone F1. 2. In regenerating liver, DNA synthesis is preceded by phosphorylation of histone F1. 3. Exposure to ionizing radiation in vivo decreases and delays the phosphorylation of histone F1 in regenerating liver, and decreases it in the hyperplastic kidney. 4. Histone F1 is phosphorylated to a greater extent in dividing than in resting tissues.
ISSN:	0264-6021 0306-3283 1470-8728
DOI:	10.1042/bj1100187