Adenosine 3':5'-cyclic monophosphate production and steroidogenesis by isolated rat adrenal glomerulosa cells. Effects of angiotensin II and [Sar 1,Ala 8]angiotensin II

Angiotensin II effects on cyclic AMP production and steroid output were studied in a sensitive preparation of isolated rat adrenal glomerulosa cells. With increasing concentrations of angiotensin II logarithmic dose-response curves for aldosterone and cyclic AMP production were similar. The minimum...

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Veröffentlicht in:	Biochemical journal 1978-10, Vol.176 (1), p.39-45
Hauptverfasser:	Bing, R F, Schulster, D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal Glands - cytology Adrenal Glands - drug effects Adrenal Glands - metabolism Aldosterone - biosynthesis Angiotensin II - pharmacology Animals Cellular Interactions and Control Processes Corticosterone - biosynthesis Cyclic AMP - biosynthesis Female In Vitro Techniques Potassium - pharmacology Rats Saralasin - pharmacology Serotonin - pharmacology
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Zusammenfassung:	Angiotensin II effects on cyclic AMP production and steroid output were studied in a sensitive preparation of isolated rat adrenal glomerulosa cells. With increasing concentrations of angiotensin II logarithmic dose-response curves for aldosterone and cyclic AMP production were similar. The minimum effective dose (0.2nm) for stimulation of aldosterone production also significantly (P
ISSN:	0264-6021 1470-8728
DOI:	10.1042/bj1760039