Associations between phenol and paraben exposure and the risk of developing breast cancer in adult women: a cross-sectional study

Increasing evidence suggests that endocrine-disrupting chemicals (EDCs) have adverse effects on breast cancer (BC). The aim of this study was to assess the association between exposure to prevalent EDCs—phenols and parabens—and the risk of developing BC. Data on urinary bisphenol A (BPA), triclosan (TRS), benzophenone-3 (BP3), methyl paraben (MPB), ethyl paraben (EPB), propyl paraben (PPB), and butyl paraben (BUP) were obtained from the 2005–2014 National Health and Nutrition Examination Survey. A total of 4455 subjects were included in this cross-sectional study. The results from the weighted multivariable regression models indicated that exposure to elevated concentrations of TRS increased the risk of developing BC by 2.33 (Q2: 95% CI = 1.45–3.75, p