The metabolism of 3,5-di-tert.-butylphenyl N-methylcarbamate in insects and by mouse liver enzymes

The metabolism of 3,5-di-tert.-butylphenyl N-methylcarbamate in insects and by mouse liver enzymes

The oxidation of 3,5-di-tert.-butylphenyl N-methylcarbamate (Butacarb) has been studied in the flies Musca domestica and Lucilia sericata, grass grubs Costelytra zealandica and the mouse. In all species eleven oxidation products, which were formed by hydroxylation of the tert.-butyl groups and the N...

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Veröffentlicht in:Biochemical journal 1971-11, Vol.125 (2), p.395-400
Hauptverfasser: Douch, P G, Smith, J N
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Carbamates - metabolism
Chromatography, Gas
Chromatography, Paper
Coleoptera
Diptera
Houseflies
Insecticides - metabolism
Larva
Liver - enzymology
Mice
Oxidation-Reduction
Phenols - metabolism
Tritium
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Zusammenfassung:The oxidation of 3,5-di-tert.-butylphenyl N-methylcarbamate (Butacarb) has been studied in the flies Musca domestica and Lucilia sericata, grass grubs Costelytra zealandica and the mouse. In all species eleven oxidation products, which were formed by hydroxylation of the tert.-butyl groups and the N-methyl group, were detected.
ISSN:0264-6021
0306-3283
1470-8728
DOI:10.1042/bj1250395