Analysis of the Macaca mulatta transcriptome and the sequence divergence between Macaca and human

We report the initial sequencing and comparative analysis of the Macaca mulatta transcriptome. Cloned sequences from 11 tissues, nine animals, and three species (M. mulatta, M. fascicularis, and M. nemestrina) were sampled, resulting in the generation of 48,642 sequence reads. These data represent a...

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Veröffentlicht in:	Genome Biology (Online Edition) 2005-01, Vol.6 (7), p.R60-1095, Article R60
Hauptverfasser:	Magness, Charles L, Fellin, P Campion, Thomas, Matthew J, Korth, Marcus J, Agy, Michael B, Proll, Sean C, Fitzgibbon, Matthew, Scherer, Christina A, Miner, Douglas G, Katze, Michael G, Iadonato, Shawn P
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Amino acids Analysis Animals Base Sequence Biochemistry Cloning, Molecular Databases, Nucleic Acid DNA Primers DNA, Complementary - genetics Evolution, Molecular Gene expression Gene Library Genes Genetic Variation Genomes Genomics Human genome Humans Macaca fascicularis - genetics Macaca mulatta Macaca nemestrina - genetics Method Molecular biology Oligonucleotide Array Sequence Analysis Sequence Homology, Nucleic Acid Technology Transcription, Genetic transcriptome
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Beschreibung
Zusammenfassung:	We report the initial sequencing and comparative analysis of the Macaca mulatta transcriptome. Cloned sequences from 11 tissues, nine animals, and three species (M. mulatta, M. fascicularis, and M. nemestrina) were sampled, resulting in the generation of 48,642 sequence reads. These data represent an initial sampling of the putative rhesus orthologs for 6,216 human genes. Mean nucleotide diversity within M. mulatta and sequence divergence among M. fascicularis, M. nemestrina, and M. mulatta are also reported.
ISSN:	1474-760X 1465-6906 1474-760X 1465-6914
DOI:	10.1186/gb-2005-6-7-r60